Results 301 to 310 of about 292,166 (318)
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Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences
Science, 1995Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear envelope followed by translocation through the nuclear pore. A recombinant human protein, hSRP1 alpha, bound in vitro specifically and directly to substrates containing either a simple or bipartite ...
Weis, Karsten +2 more
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Characterization of a nuclear localization sequence in the polyomavirus capsid protein VP1
Virology, 1991Expression of VP1-beta-galactosidase fusion proteins in the yeast Saccharomyces cerevisiae was used to identify a domain of the polyomavirus VP1 capsid protein which targets this protein to the nucleus. Fusion of the first 17 amino acids of VP1 to beta-galactosidase was sufficient for nuclear localization, whereas fusion of the first 12 amino acids ...
R B, Moreland, R L, Garcea
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A Nuclear Localization Sequence Endows Human Pancreatic Ribonuclease with Cytotoxic Activity
Biochemistry, 2004Some members of the ribonuclease superfamily, such as Onconase, are cytotoxic to cancer cells. This is not the case for human pancreatic ribonuclease. This lack of cytotoxicity is probably a result of the inhibition exerted by the cytosolic ribonuclease inhibitor once the protein has reached the cytosol.
Bosch, Montserrat +5 more
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Insights into nuclear localization sequence binding by importin alpha
2023Importin (IMP) ! is a nuclear import receptor that recognizes cargo proteinscontaining classic nuclear localization sequences (NLSs) and facilitates their transportinto the nucleus. Although NLS-binding regions are highly conserved, the sixdifferent IMP !s in mammals show distinct NLS-binding specificities.
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Specific Nuclear Localization Sequence Binding to Plant Nuclei
1994The import of proteins into the nucleus is mediated by nuclear localization sequences (NLSs), which are short polypeptide regions having a high content of basic amino acids (for reviews, see Roberts, 1989; Garcia-Bustos et al., 1991; Raikhel, 1992).
Glenn R. Hicks +2 more
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The sequence [EKRKI(E/R)(K/L/R/S/T)] is a nuclear localization signal for importin 7 binding (NLS7)
Biochimica Et Biophysica Acta - General Subjects, 2021Athanasios A Panagiotopoulos +2 more
exaly
The Fluorinated and Chlorinated Nuclear Localization Sequence of the SV 40 T Antigen
Chemical Biology and Drug Design, 2009Alexander Sturzu, Stefan Heckl
exaly