Results 321 to 330 of about 709,714 (368)

Golgin45 assists mitosis via its nuclear localization sequence.

Biochemical and Biophysical Research Communications
In mammalian cells, the Golgi apparatus undergoes fragmentation for its correct partition into two daughter cells during mitosis. Several Golgi structural proteins have been demonstrated to regulate Golgi disassembly/reassembly and spindle formation. However, it is largely unknown whether Golgi proteins mediate other major events in mitosis.
Jingkai Gao, Lianhui Zhu, Xihua Yue, Shuaiyang Jing, Shuocheng Tang, Intaek Lee, Yi Qian   +6 more
semanticscholar   +3 more sources

Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles [PDF]

ACS Nano, 2021
Directing nanoparticles to the nucleus by attachment of nuclear localization sequences (NLS) is an aim in many applications. Gold nanoparticles modified with two different NLS were studied while crossing barriers of intact cells, including uptake, endosomal escape, and nuclear translocation.
Daniela Drescher, Tina Büchner, Petra Schrade, Heike Traub, Stephan Werner, Peter Guttmann, Sebastian Bachmann, Janina Kneipp   +7 more
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14‐3‐3 protein masks the nuclear localization sequence of caspase‐2

The FEBS Journal, 2018
Caspase‐2 is an apical protease responsible for the proteolysis of cellular substrates directly involved in mediating apoptotic signaling cascades. Caspase‐2 activation is inhibited by phosphorylation followed by binding to the scaffolding protein 14‐3‐3,
A. Šmídová, M. Alblova, D. Kalábová, Katarina Psenakova, M. Rosůlek, P. Heřman, T. Obsil, V. Obsilova   +7 more
semanticscholar   +1 more source

Sequence Determinants for hnRNP I Protein Nuclear Localization

Experimental Cell Research, 1997
hnRNP I, also referred to as polypyrimidine tract binding protein, is one of the proteins associated with nascent pre-mRNA in the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. As for all karyophilic proteins, the nuclear import of hnRNP proteins requires specific sequence determinants that in many instances differ from the canonical import
Romanelli M. G., Weighardt F., Biamonti G., Riva S., Morandi C.   +4 more
openaire   +4 more sources

Centromere sequences localize to the nuclear halo of human spermatozoa

International Journal of Andrology, 1998
Chromatin is organized into a series of discrete nuclear matrix‐associated and non‐nuclear matrix‐associated domains. The non‐matrix‐associated domains consist of loops of DNA that are attached to the proteinaceous nuclear matrix by matrix‐associated regions (MARs). Although this organization is well characterized in somatic cells, comparatively little
Yuval Yaron, S. A. Krawetz, M. P. Johnson, J. A. Kramer, M. I. Evans, Saleh A.D. Ebrahim, K. Gyi   +6 more
openaire   +3 more sources

Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate.

Bioconjugate chemistry, 2011
The nonviral vector with iodine-nuclear localization sequence (namely, NLS-I) targeting breast cancer cells was fabricated. Ternary complexes were formed via charge interactions among NLS-I peptides, PEI 1800, and DNA, and we investigated their cellular ...
Hui-Yuan Wang, Cao Li, Wen-jie Yi, Yun‐Xia Sun, Si-Xue Cheng, R. Zhuo, Xianzheng Zhang   +6 more
semanticscholar   +1 more source

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

Science, 1995
Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear envelope followed by translocation through the nuclear pore. A recombinant human protein, hSRP1 alpha, bound in vitro specifically and directly to substrates containing either a simple or bipartite ...
Weis, Karsten, Mattaj, Iain W., Lamond, Angus I.   +2 more
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Localization of AT-rich sequences at the nuclear matrix

Cell Biology International Reports, 1986
After culture with 3H-thymidine murine erythroleukemia cells with more sites of DNA attached to the nuclear matrix have more labeled thymidine in their matrix-bound DNA than in their total DNA than do cells with fewer attachment sites. This indicates that the average attachment site sequence is enriched in A + T base pairs.
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