Results 111 to 120 of about 226,269 (286)

Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells

Iranian Journal of Medical Sciences, 2017
Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway.
Marie Saghaeian Jazi, Seyed Mahmoud Arab Najafi   +1 more
doaj  

Correction: Corrigendum: Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity [PDF]

, 2014
Margret H. Bülow, Torsten R. Bülow, Michael Hoch, Michael J. Pankratz, Martin A. Jünger   +4 more
openalex   +1 more source

Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

, 2021
Yoonhee Bae, Jell Lee, Changwon Kho, Joon Sig Choi, Jin Han   +4 more
openalex   +2 more sources

Binding of viral nuclear localization signal peptides to importin-α nuclear transport protein [PDF]

, 2023
Bryan M. Delfing, Xavier E. Laracuente, Audrey Olson, Kenneth W. Foreman, Mikell Paige, Kylene Kehn‐Hall, Christopher Lockhart, Dmitri K. Klimov   +7 more
openalex   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Two nuclear localization signals regulate intracellular localization of the Duck enteritis virus UL13 protein [PDF]

, 2020
Linjiang Yang, Xixia Hu, Anchun Cheng, Mingshu Wang, Renyong Jia, Qiao Yang, Ying Wu, Shun Chen, Mafeng Liu, Dekang Zhu, Xumin Ou, Xingjian Wen, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Juan Huang, Qun Gao, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Xiaoyue Chen   +24 more
openalex   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Motif of 76KRKCSK in Bm65 Is an Efficient Nuclear Localization Signal Involved in Production of Infectious Virions [PDF]

, 2019
Guohui Li, Xinyu Qi, Huiqing Chen, Zhaoyang Hu, Fangying Chen, Liang Deng, Zhongjian Guo, Keping Chen, Qi Tang   +8 more
openalex   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin α1 [PDF]

, 2011
Kaylen Lott, Anshul Bhardwaj, Peter J. Sims, Gino Cingolani   +3 more
openalex   +1 more source