Results 121 to 130 of about 345,890 (219)

Exploring the modulation of the complex folding landscape of Human Telomeric DNA by low molecular weight ligands

Chemistry – A European Journal, Accepted Article.
Telomeric DNA forms G‐quadruplex (G4) structures. These G4s structures are crucial for genomic stability and therapeutic targeting. Using time‐resolved NMR and CD spectroscopies, we investigated how the ligand Phen‐DC3 modulates the folding of the human telomeric repeat 23TAG DNA.
Ines Burkhart, Julia Wirmer-Bartoschek, Janez Plavec, Harald Schwalbe   +3 more
wiley   +1 more source

Nonadditive CO2 Uptake of Type II Porous Liquids Based on Imine Cages

ChemPhysChem, EarlyView.
Type II porous liquids based on porous imine cages (CC13/CC19) show non‐additive CO2 uptake, surpassing ideal volume additivity predictions. Experiments and simulations reveal enhanced gas absorption, with CO2 partitioning into cage pores and solvent.
Lu Lu, Chao‐Wen Chang, Stephen Schuyten, Ankana Roy, David S. Sholl, Ryan P. Lively   +5 more
wiley   +1 more source

127I Solid‐State NMR Spectroscopy of Organic Periodates Featuring Halogen Bonded IO4− ⋅ ⋅ ⋅ IO4− Adducts

ChemPhysChem, EarlyView.
A series of periodate salts, both with and without halogen bonds, were investigated using 127I solid‐state NMR at three different magnetic fields. The presence of halogen bonds affects the resulting 127I SSNMR spectra, helping in the discrimination between halogen bond‐based adducts and control samples. Abstract Hydroxyanions and oxyanions can overcome
Roberta Beccaria, Andrea Pizzi, Giuseppe Resnati, David L. Bryce   +3 more
wiley   +1 more source

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Drug Design, Development and Therapy, 2016
Norlaily Mohd Ali,1 M Nadeem Akhtar,2 Huynh Ky,3 Kian Lam Lim,1 Nadiah Abu,4 Seema Zareen,2 Wan Yong Ho,5 Han Kiat Alan-Ong,1 Sheau Wei Tan,6 Noorjahan Banu Alitheen,4 Jamil bin Ismail,2 Swee Keong Yeap,6 Tunku Kamarul7 1Faculty of Medicine and Health ...
Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T   +12 more
doaj  

Computational Studies of Enzymes for C−F Bond Degradation and Functionalization

ChemPhysChem, EarlyView.
Enzyme‐mediated strategies for C−F bond cleavage offer a promising solution for addressing the environmental challenges posed by the Forever Chemicals. This review discusses how computational approaches – including molecular docking, molecular dynamics, QM/MM, and bioinformatics – enhance the understanding of enzymatic degradation mechanisms, guiding ...
Kendra M. Cunningham, Wook Shin, Zhongyue J. Yang   +2 more
wiley   +1 more source

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

International Journal of Nanomedicine, 2010
Tessy López1–3, José L Bata-García4, Dulce Esquivel5,2, Emma Ortiz-Islas2, Richard Gonzalez3, Jorge Ascencio6, Patricia Quintana7, Gerko Oskam7, Fernando J Álvarez-Cervera4, Francisco J Heredia-L& ...
Tessy López, José L Bata-García, Dulce Esquivel, et al   +3 more
doaj  

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, Accepted Article.
In recent years, gold nanoparticles (AuNPs) have attracted much attention due to their extensive applications in fields such as biomedicine, electronics, catalysis, and environmental science. However, traditional chemical methods for AuNPs synthesis present certain challenges, such as the use of harsh chemicals and high energy consumption.
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

Metal Nitride Catalysts for Photoelectrochemical and Electrochemical Catalysis

Exploration, EarlyView.
Metal nitrides exhibit excellent electrical conductivity and catalytic activity, making them promising for (photo)electrochemical reactions. This review explores their electronic structure, surface chemistry, and synthesis strategies, emphasizing morphology and phase control.
Hee Ryeong Kwon, Jin Wook Yang, Ho Won Jang   +2 more
wiley   +1 more source