Results 121 to 130 of about 809,360 (285)

Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization and Enhance Adipogenesis through Morphological Changes [PDF]

, 2021
Zahra Allahyari, Stephanie M. Casillo, Spencer J. Perry, Ana P. Peredo, Shayan Gholizadeh, Thomas R. Gaborski   +5 more
openalex   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Fluorescently labeled nuclear morphology is highly informative of neurotoxicity. [PDF]

Front Toxicol, 2022
Wang S, Linsley JW, Linsley DA, Lamstein J, Finkbeiner S.   +4 more
europepmc   +1 more source

A high-throughput method for unbiased quantitation and categorisation of nuclear morphology [PDF]

, 2018
Benjamin M. Skinner, Claudia Cattoni Rathje, Joanne Bacon, Emma Elizabeth Philippa Johnson, Erica L. Larson, Emily E. K. Kopania, Jeffrey M. Good, Gullalaii Yousafzai, Nabeel A. Affara, Peter J. I. Ellis   +9 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer's disease mouse brains. [PDF]

Front Cell Dev Biol, 2023
Das S, Ramanan N.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Nuclear morphology is a deep learning biomarker of cellular senescence. [PDF]

Nat Aging, 2022
Heckenbach I, Mkrtchyan GV, Ezra MB, Bakula D, Madsen JS, Nielsen MH, Oró D, Osborne B, Covarrubias AJ, Idda ML, Gorospe M, Mortensen L, Verdin E, Westendorp R, Scheibye-Knudsen M.   +14 more
europepmc   +1 more source

Acute myeloid leukemia with “cup-like” nuclear morphology, highlighting the electron microscopic features

, 2017
Yoshimasa Kamoda, Daiki Shimomura, Katsuyo Tsuda, Masahiko Hayashida, Katsuhiro Fukutsuka, Kiyotaka Izumi, W. Maruyama, Yuya Nagai, Futoshi Iioka, Takashi Akasaka, Hitoshi Ohno   +10 more
openalex   +2 more sources

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells [PDF]

, 2019
Eva Pohl, Verena Höffken, Stefan Schlatt, Sabine Kliesch, Jörg Gromoll, Joachim Wistuba   +5 more
openalex   +1 more source