Results 121 to 130 of about 623,335 (318)

Detecting Selective Protein Binding Inside Plasmonic Nanopores: Toward a Mimic of the Nuclear Pore Complex

Frontiers in Chemistry, 2018
Biosensors based on plasmonic nanostructures offer label-free and real-time monitoring of biomolecular interactions. However, so do many other surface sensitive techniques with equal or better resolution in terms of surface coverage.
Bita Malekian, Rafael L. Schoch, Timothy Robson, Gustav Ferrand -Drake del Castillo, Kunli Xiong, Gustav Emilsson, Larisa E. Kapinos, Roderick Y. H. Lim, Andreas Dahlin   +8 more
doaj   +1 more source

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

Nature Communications, 2020
The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid ...
Paula Aguilera, Jenna Whalen, Christopher Minguet, Dmitri Churikov, Catherine Freudenreich, Marie-Noëlle Simon, Vincent Géli   +6 more
doaj   +1 more source

Cell development obeys maximum Fisher information [PDF]

arXiv, 2014
Eukaryotic cell development has been optimized by natural selection to obey maximal intracellular flux of messenger proteins. This, in turn, implies maximum Fisher information on angular position about a target nuclear pore complex (NPR). The cell is simply modeled as spherical, with cell membrane (CM) diameter 10 micron and concentric nuclear membrane
arxiv  

Inner/Outer Nuclear Membrane Fusion in Nuclear Pore Assembly: Biochemical Demonstration and Molecular Analysis [PDF]

The nuclear pore complex (NPC) is characterized by a long-lived membrane-lined channel connecting the inner and outer nuclear membranes. This stabilized membrane channel, within which the nuclear pore is built, has little evolutionary precedent.
Amnon Harel, Anderson D. J., Antonin W., Antonin W., Baur T., Beck M., Belgareh N., Beth Rasala, Bishop W. R., Blobel C. P., Blower M. D., Boehmer T., Boman A. L., Boris Fichtman, Brohawn S. G., Burke B., Buton X., Chakraborty P., Chernomordik L. V., Chernomordik L. V., Chernomordik L. V., Chernomordik L. V., Chernomordik L. V., Chernomordik L. V., Chernomordik L. V., Cilia M. L., Cohen M., Corinne Ramos, Cotter L. A., Crisp M., D'Angelo M. A., D'Angelo M. A., Davuluri G., Dawson T. R., de Bruyn Kops A., de Jong-Curtain T. A., Debler E. W., Dechat T., DeGrasse J. A., Devos D., Doucet C. M., Douglass J. Forbes, Drummond S. P., Dultz E., Dultz E., Earp L. J., Eriksson C., Feldherr C. M., Fernandez A. G., Fort D. J., Franz C., Fridkin A., Funakoshi T., Galy V., Gerace L., Gillespie P. J., Goldberg M. W., Greber U. F., Gruenbaum Y., Guttinger S., Hallberg E., Harel A., Henderson H. I., Herrmann A., Hetzer M., Hetzer M. W., Higa M. M., Hinshaw J. E., Hodge C. A., Holaska J. M., Hu J., Huebner E., Jackson M. B., Jahn R., Kalab P., Kalab P., Karsten Weis, Keminer O., Kielian M., Kozlov M. M., Kutay U., Lang I., Lau C. K., Lenart P., Liu J., Liu Q., Lohka M. J., Lu X., Lutzmann M., Macaulay C., Madrid A. S., Mansfeld J., Marx U., Mayer A., Melia T. J., Mishra R. K., Mohler W. A., Naim B., Newport J., Newport J., Newport J. W., Olsson M., Onischenko E., Papadopulos A., Peters R., Peters R., Podbilewicz B., Rafikova E. R., Rasala B. A., Ratner G. A., Reese C., Sapir A., Saraste J., Scarcelli J. J., Schneiter R., Schoch C., Schwander M., Shibata Y., Siniossoglou S., Sondermann H., Stavru F., Stavru F., Stegmann T., Stewart C. L., Taimen P., Tzur Y. B., Vasu S., Voeltz G. K., Walther T. C., Walther T. C., Wozniak R. W., Xu Y., Zhang C.   +132 more
core   +2 more sources

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Actinomycin D and the central granules in the nuclear pore complex: Thin sectioning versus negative staining [PDF]

, 1972
Werner A. Eckert, Werner W. Franke, U. Scheer   +2 more
openalex   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Investigating the effect of particle size distribution and complex exchange dynamics on NMR spectra of ions diffusing in disordered porous carbons through a mesoscopic model [PDF]

arXiv
Ion adsorption and dynamics in porous carbons is crucial for many technologies such as energy storage and desalination. Nuclear Magnetic Resonance (NMR) spectroscopy is a key method to investigate such systems thanks to the possibility to distinguish adsorbed (in-pore) and bulk (ex-pore) species in the spectra.
arxiv  

A multi-scale model for electrokinetic transport in networks of micro-scale and nano-scale pores [PDF]

arXiv, 2016
We present an efficient and robust numerical model for simulation of electrokinetic phenomena in porous networks over a wide range of applications including energy conversion, desalination, and lab-on-a-chip systems. Coupling between fluid flow and ion transport in these networks is governed by the Poisson-Nernst-Planck-Stokes equations.
arxiv  

Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine. [PDF]

, 1987
G D Holt, C M Snow, A Senior, Robert S. Haltiwanger, Larry Gerace, Gerald W. Hart   +5 more
openalex   +1 more source