Results 141 to 150 of about 623,335 (318)
A distinct vesicle population targets membranes and pore complexes to the nuclear envelope in Xenopus eggs. [PDF]
, 1991 Guy Vigers, Manfred J. Lohka
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, 2011 dissertationThe SUMO proteases SENP1 and SENP2 are known to reside at the nuclear pore complex; however, their functional roles there remain unclear. In this study, SENP1 and SENP2 are found to regulate the nuclear pore assembly of components located at ...
Chow, Kin-Hoe
core
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Mechanobiology of the nucleus during the G2-M transition
NucleusCellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events.
Joana T. Lima, Jorge G. Ferreira
doaj +1 more source
Assembly of nuclear pore complexes in Xenopus egg extract [PDF]
, 1991 Marie‐Christine Dabauvalle +1 more
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Reconstitution of Nup157 and Nup145N into the Nup84 Complex [PDF]
, 2005 About 30 different nucleoporins (Nups) constitute the nuclear pore complex. We have affinity-purified 28 of these nuclear pore proteins and identified new nucleoporin interactions by this analysis.
Böttcher, Bettina +6 more
core
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex [PDF]
, 1998 Serguei Popov +4 more
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Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source