Results 191 to 200 of about 294,484 (344)

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Neuron, 2017
J. Grima, J. Daigle, N. Arbez, Kathleen C. Cunningham, Ke Zhang, Joseph Ochaba, Charlene Geater, Eva L. Morozko, Jennifer T. Stocksdale, Jenna C. Glatzer, Jacqueline T. Pham, Ishrat Ahmed, Qi Peng, Harsh Wadhwa, O. Pletnikova, Juan C. Troncoso, W. Duan, Solomon H. Snyder, Laura P.W. Ranum, Leslie M. Thompson, Thomas E. Lloyd, Christopher A. Ross, Jeffrey Rothstein   +22 more
semanticscholar   +1 more source

The nuclear pore complex acts as a hub for pri-miRNA transcription and processing in plants. [PDF]

Nucleic Acids Res
Gonzalo L, Gagliardi D, Zlauvinen C, Gulanicz T, Arce AL, Fernandez J, Cambiagno DA, Merchante C, Zienkiewicz A, Jarmolowski A, Manavella PA.   +10 more
europepmc   +1 more source

Structure and Function of the Nuclear Pore Complex. [PDF]

Cold Spring Harb Perspect Biol, 2022
Petrovic S, Mobbs GW, Bley CJ, Nie S, Patke A, Hoelz A.   +5 more
europepmc   +1 more source

Misdelivery at the Nuclear Pore Complex—Stopping a Virus Dead in Its Tracks [PDF]

, 2015
Justin W. Flatt, Urs F. Greber
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex. [PDF]

Cancer Discov
Yuan L, Ji W, Dwyer BG, Lu J, Bian J, Colombo GM, Martinez MJ, Fernandez D, Phillips NA, Tang MT, Zhou CW, Quispe Calla NE, Guzman Huancas C, Eckart M, Tran J, Jones HM, Qiu T, Doench JG, Rees MG, Roth JA, Cameron MD, Charville GW, Kuo CJ, Dixon SJ, Zhang T, Hinshaw SM, Gray NS, Corsello SM.   +27 more
europepmc   +1 more source

Towards reconciling structure and function in the nuclear pore complex [PDF]

, 2008
Roderick Y. H. Lim, Ueli Aebi, Birthe Fahrenkrog   +2 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dual targeting of AMRC12 and <i>Malassezia globosa</i> disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma. [PDF]

Theranostics
Hu A, Yang C, Wang Z, Wang X, Li X, Zhou S, Zhao B, Qu J, Wang X, Zheng L, Tong Q.   +10 more
europepmc   +1 more source