Results 41 to 50 of about 8,215,941 (358)

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

open access: yesGenes & Development, 1993
A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase. We have studied cyclin D1, a putative G1 cyclin, in normal diploid
ronique Baldin   +4 more
semanticscholar   +1 more source

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

open access: yesJournal of Advanced Research, 2022
Background: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion.
Nazeer Hussain Khan   +8 more
doaj   +1 more source

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

open access: yesGenes & Development, 1992
We report on the identification of a nuclear protein that serves as a dominant-negative inhibitor of the transcription factors C/EBP and LAP. A 32P-labeled LAP DNA-binding and dimerization domain "zipper probe" was used to isolate a clone that encodes a ...
D. Ron, J. Habener
semanticscholar   +1 more source

Roles of Hydrogen Sulfide Donors in Common Kidney Diseases

open access: yesFrontiers in Pharmacology, 2020
Hydrogen sulfide (H2S) plays a key role in the regulation of physiological processes in mammals. The decline in H2S level has been reported in numerous renal disorders.
Ebenezeri Erasto Ngowi   +26 more
doaj   +1 more source

Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Tissue engineering is an emerging discipline that combines engineering and life sciences. It can construct functional biological structures in vivo or in vitro to replace native tissues or organs and minimize serious shortages of donor organs during ...
Lilan Cao   +8 more
doaj   +1 more source

The monkeypox diagnosis, treatments and prevention: A review

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
The world is currently dealing with a second viral outbreak, monkeypox, which has the potential to become an epidemic after the COVID-19 pandemic.
Saadullah Khattak   +7 more
doaj   +1 more source

Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

open access: yesFrontiers in Genetics, 2013
Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a stress-induced p53-target gene whose expression is modulated by transcription factors such as p53, p73, and E2F1. TP53INP1 gene encodes two isoforms of TP53INP1 proteins, TP53INP1α and TP53INP1β,
J. Shahbazi, R. Lock, Tao Liu
semanticscholar   +1 more source

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

open access: yesViruses, 2023
Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective and efficient therapy. The F13 protein is essential for the growth and maturation of the monkeypox virus.
Yasir Ali   +8 more
doaj   +1 more source

The potential role of hydrogen sulfide in cancer cell apoptosis

open access: yesCell Death Discovery
For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions.
Wei Gao   +9 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

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