Results 51 to 60 of about 8,215,941 (358)

Phage Henu12-resistant mutant derives fitness trade-offs in Shigella dysenteriae

Microbiology Spectrum
The rapid emergence of multidrug-resistant Shigella dysenteriae strains necessitates new therapeutic approaches, such as phage therapy. Phages are considered a promising adjunct to antibiotics.
Salwa E. Gomaa, Yuhan Wang, Jingjing Li, Huiru Cao, Jiawen Shen, Xiaotao Dong, Yangyang Liu, Na Chen, Qiming Li, Zhongyi Yan, Yulu Du, Xinying Ji, Jing Zhao, Yinqiong Tu, Tieshan Teng   +14 more
doaj   +1 more source

Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy

Ophthalmology and Therapy, 2023
Glaucoma, the leading cause of irreversible blindness worldwide, is a chronic and progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber layers, which can lead to permanent loss of peripheral or central vision ...
Jun Wang, Hanke Wang, Yalong Dang
doaj   +1 more source

The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates

Frontiers in Pharmacology, 2022
RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs.
Lei Zhang, Yayu Liang, Guohui Liang, Zhili Tian, Yue Zhang, Zhihui Liu, Xinying Ji   +6 more
doaj   +1 more source

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

eLife, 2017
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this modification is mediated by m6A-selective ‘reader’ proteins of the YTH family, which ...
I. A. Roundtree, Guan-Zheng Luo, Zijie Zhang, Xiao Wang, Tao Zhou, Y. Cui, J. Sha, Xingxu Huang, Laura Guerrero, Phil Xie, Emily He, Bin Shen, Chuan He   +12 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

ILF2: a multifaceted regulator in malignant tumors and its prospects as a biomarker and therapeutic target

Frontiers in Oncology
Interleukin enhancer binding factor 2 (ILF2), formerly called nuclear factor 45 (NF45), is widely expressed in normal human tissues. ILF2 often binds to interleukin enhancer binding factor 3 (ILF3) and regulates gene expression in several ways ...
Tonglin Sun, Tonglin Sun, Xi Li, Yi Zhang, Bingwen Zou, Yan Zhang, Yan Zhang   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins [PDF]

The Journal of Cell Biology, 1997
Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bidirectional transport signal of A1. Recently, a 90-kD protein, transportin, was
M C, Siomi, P S, Eder, N, Kataoka, L, Wan, Q, Liu, G, Dreyfuss   +5 more
openaire   +2 more sources