Results 11 to 20 of about 8,612,670 (377)
Nuclear transport proteins: structure, function and disease relevance
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Prediction of nuclear proteins using SVM and HMM models
BMC Bioinformatics, 2009 Background The nucleus, a highly organized organelle, plays important role in cellular homeostasis. The nuclear proteins are crucial for chromosomal maintenance/segregation, gene expression, RNA processing/export, and many other processes.
Raghava Gajendra PS, Kumar Manish
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Joint single-cell measurements of nuclear proteins and RNA in vivo. [PDF]
Nat Methods, 2021 Chung H +9 more
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NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells. [PDF]
Nat Methods, 2022 Chen AF +5 more
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Modeling the transport of nuclear proteins along single skeletal muscle cells. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Skeletal muscle cells are unique among human cells because they contain hundreds of nuclei distributed over large distances within a shared cytoplasm.
Taylor-Weiner H +6 more
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Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. [PDF]
Nat Chem Biol, 2019 Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process.
Zhang X +4 more
europepmc +2 more sources
Single domain antibodies for the knockdown of cytosolic and nuclear proteins. [PDF]
Protein Sci, 2017 Böldicke T.
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Laminopathies: what can humans learn from fruit flies
Cellular & Molecular Biology Letters, 2018 Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the
Marta Pałka +6 more
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iScience, 2023 Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when they ...
Alexander Ewerling +3 more
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