Results 31 to 40 of about 734,603 (316)
Nuclear hormone receptors in podocytes [PDF]
Cell & Bioscience, 2012 AbstractNuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome.
Simran Khurana +2 more
openaire +4 more sources
Molecular Therapy: Oncolytics, 2020 One of the major hurdles for cancer immunotherapy is the host’s innate antiviral defense mechanisms. They include innate immune cells, such as natural killer (NK) cells and macrophages, which can be recruited within hours to the site of injection to ...
Xinping Fu +3 more
doaj
Technology in Cancer Research & Treatment, 2020 Objective: The aim of the study is to determine the role of nuclear receptor coactivator 2 in cell proliferation and invasion ability of gastric cancer cells and to explore its possible mechanisms.
Zhenlv Lin MB +5 more
doaj +1 more source
Cell, 2010 Clinical: Flutamide and bicalutamide for prostate cancer and alopeciaGlucocorticoid receptorGR/NR3C1 Endogenous: Cortisol (hydrocortisone) Diverse developmental and physiological roles (e.g., antagonism of inflammatory signaling pathways, mediation of the stress response, and gluconeogenesis)Metabolic, cardiovascular, immune and inflammatory, memory↑
Bert W. O'Malley, Neil J. McKenna
openaire +4 more sources
Nuclear Hormone Receptors in T Lymphocytes [PDF]
Cell, 2002 Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
Astar Winoto, Dan R. Littman
openaire +2 more sources
BMC Evolutionary Biology, 2009 Background Nuclear receptors are a superfamily of metazoan transcription factors that regulate diverse developmental and physiological processes.
Tarrant Ann M, Reitzel Adam M
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content.
PLoS ONE, 2014 Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated
Gianni Garcia-Faroldi +5 more
doaj +1 more source
Nuclear receptors and their coregulators in kidney [PDF]
Kidney International, 2005 Nuclear receptors are transcription factors that are essential in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and apoptosis. Dysfunction of nuclear receptor signaling leads to a wide spectra of proliferative, reproductive, and metabolic diseases, including cancers, infertility, obesity, and diabetes.
Xiong Z. Ruan +3 more
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source