Results 121 to 130 of about 36,876 (225)

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Phloretic Acid Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in High-Fat Diet-Fed Mice. [PDF]

Molecules
Park S, Kim H, Jung UJ.
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Nuclear Receptor Subfamily 4 Group A Member 1 Exacerbates Cardiac Remodeling by Inhibiting Mitochondrial Function Through the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α/Nuclear Respiratory Factor 1/Transcription Factor A Mitochondrial Axis. [PDF]

J Am Heart Assoc
Kong CY, Wang MY, Ma YL, Guo Z, Yang Z, Tang QZ.   +5 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, EarlyView.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain. [PDF]

Redox Biol
Zhang YY, Long XY, Tian J, Luo XJ, Peng J.   +4 more
europepmc   +1 more source

Unravelling the phylogeny of armadillos and their kin (Mammalia, Xenarthra, Cingulata) combining morphological, molecular, and stratigraphic data

Cladistics, EarlyView.
Abstract Cingulata, a major lineage of Xenarthra, comprises extinct and extant armoured placental mammals that diversified throughout the Cenozoic. Despite extensive study, phylogenetic hypotheses based on morphological and molecular data remain incongruent, and no total evidence analysis has been conducted. Here, we integrate the largest morphological
Daniel M. Casali, Mariela C. Castro, Martin R. Ciancio, Timothy J. Gaudin, Jeremy L. Bramblett, Alberto Boscaini, Fernando A. Perini, Max C. Langer   +7 more
wiley   +1 more source

Bempedoic acid within the phase ternary diagram governing biliary cholesterol solubilization and gallstone risk. [PDF]

J Lipid Res
Di Ciaula A, Khalil M, Garruti G, Portincasa P.   +3 more
europepmc   +1 more source

Evolutionary framework and tribal circumscription of Amaranthaceae sensu stricto based on a comprehensive phylogenomic analysis

Cladistics, EarlyView.
Abstract The evolutionary history of Amaranthaceae sensu stricto (s.s.) has been shaped by multiple whole‐genome duplications and rapid radiations, producing an ecologically diverse lineage whose internal relationships have long remained unresolved.
Tina Kiedaisch, Anže Žerdoner Čalasan, Ross A. McCauley, Gudrun Kadereit   +3 more
wiley   +1 more source