Results 141 to 150 of about 36,876 (225)

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window. [PDF]

Actas Esp Psiquiatr
Becerra López JA, Genis Mendoza AD, Nicolini H.   +2 more
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway. [PDF]

World J Gastroenterol
Xu T, Hou WX, Yang ST, Shao YP, Wang J, Han TT, Li JN.   +6 more
europepmc   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

CRISPR decodes the RNA regulatory network in prostate cancer: A review from mechanisms to precision therapeutics. [PDF]

Noncoding RNA Res
Zhu S, Ni G, Zhang P, Yang Y, He H, Jiang J, Li Z.   +6 more
europepmc   +1 more source

Insights into tandem dioxygenases—copper radical oxidases in fungal Phytopathogens of the Colletotrichum acutatum species complex

The FEBS Journal, EarlyView.
In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková, David Ribeaucourt, Mireille Haon, David Navarro, Elodie Drula, Bastien Bissaro, Jean‐Guy Berrin, Mickael Lafond   +7 more
wiley   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Targeting Pathways Implicated in Cholesterol Metabolism for Novel Cancer Therapy. [PDF]

Cancers (Basel)
Zhou Y, Sharma V, Li X, Singla RK, Kumar A, Kyada A, Ballal S, Nathiya D, Koul A, Khalid M, Gulati M, Arora S, Behl T, Kavalakatt J, Shen B, Bishayee A.   +15 more
europepmc   +1 more source

Improving Decision‐Making in the Identification of Tephritidae Larvae at Import in the European Union and Key to Third Instar Larvae

Journal of Applied Entomology, EarlyView.
ABSTRACT The Tephritidae family, or true fruit flies, comprises approximately 250 species recognized as economically significant due to their capacity to infest commercial fruits. These pests pose serious threats to both food security and trade, and are considered quarantine pests in areas where they are not yet established. In the European Union (EU),
Andrea Taddei, Pascal Rousse, Raphaëlle Mouttet, Sarah Chérasse, Christa Lethmayer, Elena Bacher, Chiara Pohn, Richard Alexander Gottsberger, Helga Reisenzein, Philippe Reynaud   +9 more
wiley   +1 more source