Results 91 to 100 of about 624,823 (322)

Remotely piloted aircraft systems and a wireless sensors network for radiological accidents [PDF]

open access: yes, 2016
In critical radiological situations, the real time information that we could get from the disaster area becomes of great importance. However, communication systems could be affected after a radiological accident.
Barrado Muxí, Cristina   +4 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Morphological and Molecular Basis of Cytoplasmic Dilation and Swelling in Cortical Migrating Neurons

open access: yesBrain Sciences, 2017
During corticogenesis, neuronal migration is an essential step for formation of a functional brain, and abnormal migration is known to cause various neurological disorders.
Yoshiaki V. Nishimura   +2 more
doaj   +1 more source

An Introduction to Nuclear Supersymmetry: a Unification Scheme for Nuclei

open access: yes, 2004
The main ideas behind nuclear supersymmetry are presented, starting from the basic concepts of symmetry and the methods of group theory in physics. We propose new, more stringent experimental tests that probe the supersymmetry classification in nuclei ...
Balantekin   +35 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transfer characteristics of a lithium chloride–potassium chloride molten salt

open access: yesNuclear Engineering and Technology, 2017
Pyroprocessing is an alternative method of reprocessing spent fuel, usually involving the dissolving spent fuel in a molten salt media. The National Nuclear Laboratory designed, built, and commissioned a molten salt dynamics rig to investigate the ...
Eve Mullen   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Fundamental Understanding of Pebble Bed Nuclear Reactors for Environmentally Benign and Risk Free Proliferation 4th Generation Nuclear Energy and Hydrogen Production [abstract] [PDF]

open access: yes, 2009
only availableTrack I: Power GenerationPebble bed nuclear reactor is among the 6 suggested 4th generation nuclear reactors. It is also one of the advanced high temperature gas nuclear reactors (AGRs).
Abdulmohsen, M.   +3 more
core  

Nuclear Astrophysics with Radioactive Beams

open access: yes, 2009
The quest to comprehend how nuclear processes influence astrophysical phenomena is driving experimental and theoretical research programs worldwide. One of the main goals in nuclear astrophysics is to understand how energy is generated in stars, how ...
Bertulani, C. A., Gade, A.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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