Results 51 to 60 of about 624,823 (322)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Heat Transfer in Cavities: Configurative Systematic Review

open access: yesEnergies, 2023
This study is a systematic review of research on heat transfer analysis in cavities and aims to provide a comprehensive understanding of flow and heat transfer performance in various kinds of cavities with or without the presence of fins, obstacles ...
Goutam Saha   +3 more
doaj   +1 more source

CFD Applications in Energy Engineering Research and Simulation: An Introduction to Published Reviews [PDF]

open access: yes, 2019
Computational Fluid Dynamics (CFD) has been firmly established as a fundamental discipline to advancing research on energy engineering. The major progresses achieved during the last two decades both on software modelling capabilities and hardware ...
Iranzo Paricio, Jose Alfredo
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

open access: yesScientific Reports, 2023
The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms.
Guillaume A. Castillon   +5 more
doaj   +1 more source

The Effective Field Theory of Dark Matter Direct Detection

open access: yes, 2012
We extend and explore the general non-relativistic effective theory of dark matter (DM) direct detection. We describe the basic non-relativistic building blocks of operators and discuss their symmetry properties, writing down all Galilean-invariant ...
A. Liam Fitzpatrick   +12 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Improved 19F{1H} Saturation Transfer Difference Experiments for Sensitive Detection to Fluorinated Compound Bound to Proteins

open access: yesMagnetochemistry, 2018
The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection using a human serum albumin-diflunisal complex. Because NMR (nuclear magnetic resonance) experiments with 19F detection are feasible for the selective ...
Kazuo Furihata, Mitsuru Tashiro
doaj   +1 more source

Mitochondrial Donation: The UK Experience

open access: yesFertility & Reproduction, 2023
Mutations in mitochondrial DNA (mtDNA) are inherited exclusively from our mothers and can cause a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of the mitochondrial genome from the nuclear ...
Mary Herbert
doaj   +1 more source

DNA methylation in the early porcine embryo [PDF]

open access: yes
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Bonk, Aaron James, 1970-
core   +1 more source

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