Results 11 to 20 of about 788,142 (267)

A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo   +3 more
doaj   +1 more source

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

eLife, 2014
Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as ...
Benjamin JM Taylor, Yee Ling Wu, Cristina Rada   +2 more
doaj   +1 more source

Investigating the mechanism of action of hemofugal and blood-stasis-expelling soup in the treatment of coronary heart disease based on network pharmacology [PDF]

BIO Web of Conferences
Objective: To investigate the mechanism of action of Xuefu yuyuxu Tang in the treatment of Coronary Heart Disease (CHD) based on network-based pharmacology.
·yusuf Arslan, Ma Yun, Wang Qi
doaj   +1 more source

On-Chip DNA Methylation Analysis Using Osmium Complexation

Journal of Nucleic Acids, 2011
The development of a reaction for detecting the presence/absence of one methyl group in a long DNA strand is a chemically and biologically challenging research subject.
Kaori Sugizaki, Tadashi Umemoto, Akimitsu Okamoto   +2 more
doaj   +1 more source

Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation

Frontiers in Pharmacology, 2022
Cisplatin is a widely used and potent anti-neoplastic agent, but severe and inescapable side effects in multiple normal tissues and organs limit its application, especially nephrotoxicity.
Qiang Wang, Qiang Wang, Yuemei Xi, Yuemei Xi, Binyang Chen, Binyang Chen, Hairong Zhao, Hairong Zhao, Wei Yu, Wei Yu, De Xie, De Xie, Weidong Liu, Weidong Liu, Furong He, Furong He, Chenxi Xu, Chenxi Xu, Jidong Cheng, Jidong Cheng   +19 more
doaj   +1 more source

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation

Frontiers in Genetics, 2022
Over 50 million people around the world currently are suffering from Alzheimer’s disease (AD) without any effective therapy. Neuroinflammation plays a pivotal role in AD, which leads us to probe the profile of immune cell infiltration in AD.
Fanmao Jin, Yuemei Xi, Yuemei Xi, De Xie, De Xie, Qiang Wang, Qiang Wang   +6 more
doaj   +1 more source

Identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat using PCR-RFLP technique [PDF]

Biotechnology in Animal Husbandry, 2015
PCR-RFLP technique was developed for identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat. DNA from small amount of muscles (0.05 g) was extracted and a region of mitochondrial DNA (cytochrome-b gene) in chicken,
Abdel-Rahman S.M., Elmaghraby A.M., Haggag A.S.   +2 more
doaj  

Toxicity Evaluation of Potassium Sorbate In Vivo with Drosophila Melanogaster

Insects
Potassium sorbate (PS) is a preservative widely used in the food, pharmaceutical, and cosmetics industries. Improper and careless use of PS can lead to various health issues and potential environmental problems.
Xubo Zhang, Qian Zhang, Xiaoxuan Song, Wanchen Yang, Andi Cheng, Jianzhen Zhang, Wei Dong   +6 more
doaj   +1 more source

Conformational switches control early maturation of the eukaryotic small ribosomal subunit

eLife, 2019
Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5’ external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome.
Mirjam Hunziker, Jonas Barandun, Olga Buzovetsky, Caitlin Steckler, Henrik Molina, Sebastian Klinge   +5 more
doaj   +1 more source

Developing methods to study conformational changes in RNA crystals using a photocaged ligand

Frontiers in Molecular Biosciences, 2022
Crystallographic observation of structural changes in real time requires that those changes be uniform both spatially and temporally. A primary challenge with time-resolved ligand-mixing diffraction experiments is asynchrony caused by variable factors ...
Hyun Kyung Lee, Chelsie E. Conrad, Valentin Magidson, William F. Heinz, Gary Pauly, Ping Yu, Saminathan Ramakrishnan, Jason R. Stagno, Yun-Xing Wang   +8 more
doaj   +1 more source