Results 21 to 30 of about 6,071,343 (411)

Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation

Nature, 2020
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood 1 – 3 . Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zα domains that bind Z-
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer, Juan Lin, R. Eren, Amanda Fisher, Rebecca K. Lane, G. Young, G. Kassiotis, W. Kaiser, M. Pasparakis   +11 more
semanticscholar   +1 more source

Modeling nucleic acids [PDF]

Current Opinion in Structural Biology, 2012
Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
openaire   +4 more sources

Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning

Nature Communications, 2022
Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput ...
Rachapun Rotrattanadumrong, Yohei Yokobayashi   +1 more
doaj   +1 more source

Breathing Life into Polycations [PDF]

, 2008
The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin, Oskuee, Reza, Philipp, Alexander, Schmidt, Claudia, Wagner, Ernst   +4 more
core   +1 more source

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
core   +1 more source

Nucleic Acids Analysis [PDF]

Science China Chemistry, 2020
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis ...
Zai-Sheng Wu, Juewen Liu, Hua Kuang, Chao Zhang, Lihua Wang, Chaoyong Yang, Chaoyong Yang, Da Han, Changlong Hao, Qian Li, Min Li, Libing Liu, Fang Luo, Jianbin Wang, Jiang Li, Chunhai Fan, Xiaolei Zuo, Fujian Huang, Yan-Ru Chen, Huanghao Yang, Lingling Wu, Zhi Zhu, Bo Tang, Zhenyu Lin, Jiashu Sun, Xiuhai Mao, Dingbin Liu, Bi-Feng Yuan, Shu Wang, Fei Wang, Chun-Hua Lu, Yanyi Huang, Jinqi Deng, Xiaoguo Liu, Guoliang Ke, Fan Xia, Quan Yuan, Na Li, Xiao-Bing Zhang, Yongxi Zhao, Feng Chen, Fan Li, Weihong Tan, Weihong Tan, Yang Yang, Chuanlai Xu   +45 more
openaire   +2 more sources

Stability of nucleic acid bases in concentrated sulfuric acid: Implications for the habitability of Venus' clouds [PDF]

PNAS, June 12, 2023, 120 (25) e2220007120, 2023
What constitutes a habitable planet is a frontier to be explored and requires pushing the boundaries of our terracentric viewpoint for what we deem to be a habitable environment. Despite Venus' 700 K surface temperature being too hot for any plausible solvent and most organic covalent chemistry, Venus' cloud-filled atmosphere layers at 48 to 60 km ...
arxiv   +1 more source

An ultrasensitive photoelectrochemical nucleic acid biosensor [PDF]

, 2005
A simple and ultrasensitive procedure for non-labeling detection of nucleic acids is described in this study. It is based on the photoelectrochemical detection of target nucleic acids by forming a nucleic acid/photoreporter adduct layer on an ITO ...
Gao, Zhiqiang, Tansil, Natalia C.
core   +3 more sources

A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo   +3 more
doaj   +1 more source

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]

, 2015
Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric, Hartono, Stella R, Lim, Yoong Wearn, Sanz, Lionel A, Xu, Xiaoqin   +4 more
core   +2 more sources