Results 41 to 50 of about 6,135,044 (385)

Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation

Nature, 2020
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood 1 – 3 . Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zα domains that bind Z-
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer, Juan Lin, R. Eren, Amanda Fisher, Rebecca K. Lane, G. Young, G. Kassiotis, W. Kaiser, M. Pasparakis   +11 more
semanticscholar   +1 more source

A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo   +3 more
doaj   +1 more source

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

eLife, 2014
Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as ...
Benjamin JM Taylor, Yee Ling Wu, Cristina Rada   +2 more
doaj   +1 more source

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]

, 2015
Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric, Hartono, Stella R, Lim, Yoong Wearn, Sanz, Lionel A, Xu, Xiaoqin   +4 more
core   +2 more sources

Investigating the mechanism of action of hemofugal and blood-stasis-expelling soup in the treatment of coronary heart disease based on network pharmacology [PDF]

BIO Web of Conferences
Objective: To investigate the mechanism of action of Xuefu yuyuxu Tang in the treatment of Coronary Heart Disease (CHD) based on network-based pharmacology.
·yusuf Arslan, Ma Yun, Wang Qi
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation

Frontiers in Genetics, 2022
Over 50 million people around the world currently are suffering from Alzheimer’s disease (AD) without any effective therapy. Neuroinflammation plays a pivotal role in AD, which leads us to probe the profile of immune cell infiltration in AD.
Fanmao Jin, Yuemei Xi, Yuemei Xi, De Xie, De Xie, Qiang Wang, Qiang Wang   +6 more
doaj   +1 more source

Helicase processivity and not the unwinding velocity exhibits universal increase with force [PDF]

, 2015
Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex nucleic acid.
Chakrabarti, Shaon, Pincus, David L., Thirumalai, D.   +2 more
core   +2 more sources

Nucleic acid memory [PDF]

Nature Materials, 2016
Nucleic acid memory has a retention time far exceeding electronic memory. As an alternative storage media, DNA surpasses the information density and energy of operation offered by flash memory.
Zhirnov, Victor, Zadegan, Reza M., Sandhu, Gurtej S., Church, George M., Hughes, William L.   +4 more
openaire   +4 more sources

Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation

Frontiers in Pharmacology, 2022
Cisplatin is a widely used and potent anti-neoplastic agent, but severe and inescapable side effects in multiple normal tissues and organs limit its application, especially nephrotoxicity.
Qiang Wang, Qiang Wang, Yuemei Xi, Yuemei Xi, Binyang Chen, Binyang Chen, Hairong Zhao, Hairong Zhao, Wei Yu, Wei Yu, De Xie, De Xie, Weidong Liu, Weidong Liu, Furong He, Furong He, Chenxi Xu, Chenxi Xu, Jidong Cheng, Jidong Cheng   +19 more
doaj   +1 more source