Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides. [PDF]
Bioconjug Chem, 2020 Chemoselective transformations that work under physiological conditions have emerged as powerful tools to label nucleic acids in cell-free and cellular environments.
Walunj MB, Srivatsan SG.
europepmc +2 more sources
Dependence of interferon induction on nucleic acid conformation. [PDF]
Proceedings of the National Academy of Sciences, 1976 UV and circular dichroism characteristics of duplex analogs belonging to the (A)n-(U)n and (I)n-(C)n series were determined to assign qualitatively the nature of conformational differences caused by 5-pyrimidine and c7 purine substitutions in such ...
A. Bobst +3 more
semanticscholar +4 more sources
Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions [PDF]
Journal of Nucleic Acids, 2011 Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano +2 more
doaj +4 more sources
Global Studies of Single-Stranded Nucleic Acid Conformation [PDF]
Biophysical Journal, 2013 Unstructured regions of RNA molecules require flexibility to accomplish many biological tasks such as conformational switching and protein recognition. Due to its highly charged backbone, the flexibility of single-stranded RNA is influenced by counterions.
Julie L. Sutton +3 more
semanticscholar +3 more sources
The electrostatic field of DNA: the role of the nucleic acid conformation.
Nucleic Acids Research, 1982 Calculations of the electrostatic field of DNA in two very different double helical conformations, A and Z, are reported and compared with the results previously obtained for B-DNA. Striking contrasts between these fields and the associated electrostatic
R. Lavery, B. Pullman
semanticscholar +6 more sources
Sensing the structural and conformational properties of single-stranded nucleic acids using electrometry and molecular simulations [PDF]
Scientific ReportsInferring the 3D structure and conformation of disordered biomolecules, e.g., single stranded nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in solution.
Rowan Walker-Gibbons +4 more
doaj +2 more sources
The Z-nucleic acid sensor ZBP1 in health and disease
Journal of Experimental Medicine, 2023 ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer.
J. Maelfait, J. Rehwinkel
semanticscholar +1 more source
Modelling aptamers with nucleic acid mimics (NAM): From sequence to three-dimensional docking
PLoS ONE, 2022 Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional structures.
Ricardo Oliveira +5 more
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Developing Community Resources for Nucleic Acid Structures
Life, 2022 In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers University and how it became a testbed for the current infrastructure of the RCSB Protein Data Bank. We describe some of the special features of the NDB and how it has
Helen M. Berman +2 more
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Effects of 2'-O-methyl nucleotide substitution on EcoRI endonuclease cleavage activities. [PDF]
PLoS ONE, 2013 To investigate the effect of sugar pucker conformation on DNA-protein interactions, we used 2'-O-methyl nucleotide (2'-OMeN) to modify the EcoRI recognition sequence -TGAATTCT-, and monitored the enzymatic cleavage process using FRET method.
Guojie Zhao +4 more
doaj +1 more source