Results 1 to 10 of about 194,899 (239)
Some of the next articles are maybe not open access.
Conformational geometry and vibrational frequencies of nucleic acid chains
Biopolymers, 1975AbstractNormal coordinate analysis of diethyl phosphate has been made, which predicts all observed Raman frequencies in the range 170–1300 cm−1. The force constants from this calculation have been transferred to a vibrational calculation for a simplified model of the backbone of nucleic acids, which also involves the OPO2−O phosphate group and the ...
Ellen B. Brown, Warner L. Peticolas
openaire +3 more sources
Alternative conformations of a nucleic acid four-way junction
Journal of Molecular Biology, 2000A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches.
Gerald F. Joyce+3 more
openaire +3 more sources
Copper(II)-Nucleic acid interactions—A conformational study
Journal of Theoretical Biology, 1979Abstract The effect of copper complexation upon the conformational angles in mononucleotides and dinucleotides was studied using classical potential energy expressions. The geometrical parameters were taken from crystallographic reports on the base-metal complexes.
B.K. Sathyanarayana, Jagdeesh Bandekar
openaire +3 more sources
Quantum-Mechanical Studies on the Conformation of Nucleic Acids and Their Constituents
1976Publisher Summary This chapter discusses the results of the quantum-mechanical computations of the conformational properties of nucleic acids and their constituents, comparing the results obtained by different methods among themselves with the results of the empirical computations, and with the available experimental data as obtained by different ...
Anil Saran, Bernard Pullman
openaire +3 more sources
Theoretical Probes of Nucleic Acid Conformation
1983The computations described briefly here illustrate the interrelationship between the local structure and macroscopic behavior of the DNA helix. Statistical mechanical studies help to identify the most likely morphological arrangements of the polynucleotide backbone and to understand the macroscopic flexibility of the DNA as a whole.
openaire +2 more sources
Influence of Lipid Membranes on the Conformational Transitions of Nucleic Acids
Journal of Biomolecular Structure and Dynamics, 1986The conformational transitions of nucleic acids which were enclosed in reverse phase evaporation vesicles (REV) were studied by thermal denaturation with optical recording. Cloned fragments of double-stranded DNA containing 179 base pairs and 187 base pairs, respectively, and polyA.polyU were enclosed in REV with a yield up to every vesicle containing ...
Bernhard Brosius, Detlev Riesner
openaire +3 more sources
Nucleic acid reactivity and conformation I. Deamination of cytosine by nitrous acid
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972Abstract The rate of deamination of cytosine to uracil by nitrous acid was measured under several sets of conditions for the following compounds: cytidine, cytidine 5′-phosphate, poly(cytidylic acid) (in both single-stranded and half-protonated double helix forms), and the poly(I) · poly(C) complex. The relative reactivity of nucleoside : nucleotide :
Robert Shapiro, Hisao Yamaguchi
openaire +3 more sources
Optical activity and the conformation of polynucleotide models of nucleic acids
Journal of Molecular Biology, 1965The interaction between polymers of adenylic and uridylic acids has been investigated using homopolyadenylate and homopolyuridylate, and copolymers containing various ratios of AMP and UMP randomly distributed. The measurements of circular dichroism in the region of 230 to 320 m μ indicate that the formation of the two-stranded poly (A + U)† helical ...
openaire +3 more sources
Determination of the Conformation of Nucleic Acids by Electronic CD
1996The natural and synthetic nucleic acids are polymers of nucleotides that in turn are made up of an aromatic base, a sugar, and a phosphate group. The bases are the chromophores that absorb ultraviolet light to undergo electronic transitions, which begin at 300 nm and continue into the vacuum UV region.
openaire +2 more sources
Conformational penalties: New insights into nucleic acid recognition
Current Opinion in Structural BiologyThe energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuring conformational penalties and determining their contribution to the recognition, folding, and ...
Ainan, Geng+2 more
openaire +2 more sources