Results 1 to 10 of about 201,489 (346)

Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides. [PDF]

Bioconjug Chem, 2020
Walunj MB, Srivatsan SG.
europepmc   +3 more sources

Sensing the structural and conformational properties of single-stranded nucleic acids using electrometry and molecular simulations

Scientific Reports
Inferring the 3D structure and conformation of disordered biomolecules, e.g., single stranded nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in solution.
Rowan Walker-Gibbons, Xin Zhu, Ali Behjatian, Timothy J. D. Bennett, Madhavi Krishnan   +4 more
doaj   +2 more sources

Nucleic acid stain-dependent single strand conformation polymorphisms

BioTechniques, 2004
David R. McKee, M. Scott Thomson
doaj   +2 more sources

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping [PDF]

Communications Chemistry
End capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen, Chunlei Zhang, Xue Chen, Ziwen Dai, Mengting Li, Wenjian Ma, ChiYung Yam, Xiaoluo Huang, Chenghe Xiong, Hui Mei   +9 more
doaj   +2 more sources

Modelling aptamers with nucleic acid mimics (NAM): From sequence to three-dimensional docking

PLoS ONE, 2022
Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional structures.
Ricardo Oliveira, Eva Pinho, Ana Luísa Sousa, Óscar Dias, Nuno Filipe Azevedo, Carina Almeida   +5 more
doaj   +2 more sources

Developing Community Resources for Nucleic Acid Structures

Life, 2022
In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers University and how it became a testbed for the current infrastructure of the RCSB Protein Data Bank. We describe some of the special features of the NDB and how it has
Helen M. Berman, Catherine L. Lawson, Bohdan Schneider   +2 more
doaj   +1 more source

Effects of 2'-O-methyl nucleotide substitution on EcoRI endonuclease cleavage activities. [PDF]

PLoS ONE, 2013
To investigate the effect of sugar pucker conformation on DNA-protein interactions, we used 2'-O-methyl nucleotide (2'-OMeN) to modify the EcoRI recognition sequence -TGAATTCT-, and monitored the enzymatic cleavage process using FRET method.
Guojie Zhao, Bin Zhao, Zhaoxue Tong, Runqing Mu, Yifu Guan   +4 more
doaj   +1 more source

Optimizing scoring function of protein-nucleic acid interactions with both affinity and specificity. [PDF]

PLoS ONE, 2013
Protein-nucleic acid (protein-DNA and protein-RNA) recognition is fundamental to the regulation of gene expression. Determination of the structures of the protein-nucleic acid recognition and insight into their interactions at molecular level are vital ...
Zhiqiang Yan, Jin Wang
doaj   +1 more source

Metal-Binding Antimicrobial Peptide SIF4 Kills Escherichia coli by Targeting Cytoplasmic Biomacromolecules without Cytoplasmic Membrane Damage: A Mechanistic Study [PDF]

Shipin Kexue, 2023
To explore how metal-binding antimicrobial peptide SIF4 kills foodborne Escherichia coli by targeting nucleic acid and protein in the cytoplasmic membrane without cytoplasmic membrane damage, the effect of SIF4 on intracellular nucleic acid biosynthesis ...
LI Yuzhen, XIAO Huaiqiu, LIU Miao, WANG Lin, ZENG Mengqi, ZHAO Mouming
doaj   +1 more source

Structural basis of R-loop recognition by the S9.6 monoclonal antibody

Nature Communications, 2022
The S9.6 monoclonal antibody is widely used to map R-loops genome wide. Here, Bou-Nader et al., define the nucleic acid-binding specificity of S9.6 and report its crystal structures free and bound to a hybrid, which reveal the asymmetric recognition of ...
Charles Bou-Nader, Ankur Bothra, David N. Garboczi, Stephen H. Leppla, Jinwei Zhang   +4 more
doaj   +1 more source