Results 1 to 10 of about 438,619 (385)
Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides. [PDF]
Bioconjug Chem, 2020 Chemoselective transformations that work under physiological conditions have emerged as powerful tools to label nucleic acids in cell-free and cellular environments.
Walunj MB, Srivatsan SG.
europepmc +4 more sources
Global Studies of Single-Stranded Nucleic Acid Conformation [PDF]
Biophysical Journal, 2013 Unstructured regions of RNA molecules require flexibility to accomplish many biological tasks such as conformational switching and protein recognition. Due to its highly charged backbone, the flexibility of single-stranded RNA is influenced by counterions.
Julie L. Sutton +3 more
semanticscholar +4 more sources
Dependence of interferon induction on nucleic acid conformation. [PDF]
Proceedings of the National Academy of Sciences, 1976 UV and circular dichroism characteristics of duplex analogs belonging to the (A)n-(U)n and (I)n-(C)n series were determined to assign qualitatively the nature of conformational differences caused by 5-pyrimidine and c7 purine substitutions in such duplexes.
Albert M. Bobst +3 more
semanticscholar +5 more sources
Rigid spin-labeled nucleoside Ç: a nonperturbing EPR probe of nucleic acid conformation [PDF]
Nucleic Acids Research, 2008 Rigid spin-labeled nucleoside Ç, an analog of deoxycytidine that base-pairs with deoxyguanosine, was incorporated into DNA oligomers by chemical synthesis.
Pavol Čekan +4 more
openalex +2 more sources
Conformational analysis of nucleic acids revisited: Curves+ [PDF]
Nucleic Acids Research, 2009 We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it ...
Richard Lavery +4 more
openalex +5 more sources
The electrostatic field of DNA: the role of the nucleic acid conformation
Nucleic Acids Research, 1982 Calculations of the electrostatic field of DNA in two very different double helical conformations, A and Z, are reported and compared with the results previously obtained for B-DNA. Striking contrasts between these fields and the associated electrostatic potentials are brought into evidence.
Lavery, R., Pullman, B.
openaire +6 more sources
An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping [PDF]
Communications ChemistryEnd capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen +9 more
doaj +2 more sources
Methylation Effects on Nucleic Acid Conformations [PDF]
, 1978 Chemical modification of nucleic acids by alkylating agents continues to be extensively explored from the perspective of chemical mutagenesis and carcinogenesis. Largely through the pioneering in vitro and in vivo studies of Lawley (1961), Lawley and Brookes (1963), Singer (1972), and Reese and coworkers (1965), coupled with theoretical predictions of ...
S. Danyluk +2 more
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A Nonafluoro Nucleoside as a Sensitive 19F NMR Probe of Nucleic Acid Conformation [PDF]
Organic Letters, 2008 A nucleoside carrying a perfluorinated tert-butyl group ( 4) was prepared by a Sonogashira coupling of 5-iodo-2'-deoxyuridine with 4,4,4-trifluoro-3,3-bis(trifluoromethyl)-1-butyne in nearly quantitative yield and subsequently incorporated into DNA ...
Nivrutti B. Barhate +4 more
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Scientific ReportsInferring the 3D structure and conformation of disordered biomolecules, e.g., single stranded nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in solution.
Rowan Walker-Gibbons +4 more
doaj +2 more sources