Results 211 to 220 of about 194,899 (239)

Physics of Protein Aggregation in Normal and Accelerated Brain Aging. [PDF]

Bioessays
Espay AJ, Sturchio A, Imarisio A, Hill EJ, Williamson B, Montemagno K, Hoffmann C, Roy HL, Milovanovic D, Manfredsson FP.   +9 more
europepmc   +1 more source

CONFORMATIONAL STUDIES OF NUCLEIC ACIDS

, 1984
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Calculations of nucleic acid conformations

Current Opinion in Structural Biology, 1996
The present computational power and sophistication of theoretical approaches to nucleic acid structural investigation are sufficient for the realization of static and dynamic models that correlate accurately with current crystallographic, NMR and solution-probing structural data, and consequently are able to provide valuable insights and predictions ...
Auffinger, Pascal, Louise-May, Shirley, Westhof, Eric   +2 more
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The conformations of locked nucleic acids (LNA)

Journal of Molecular Recognition, 2000
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9- and 10-mer modified oligonucleotides hybridized to unmodified DNA.
Petersen, Michael B., Nielsen, Christina B., Nielsen, Katrine E., Jensen, Gitte A., Bondensgaard, Kent, Singh, Sanjay Kumar, Rajwanshi, Vivek Kumar, Koshkin, Alexei, Dahl, Britta Mynster, Wengel, Jesper Thagaard, Jacobsen, Jens Peter   +10 more
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Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
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Two contiguous conformations in a nucleic acid duplex [PDF]

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
David R. Kearns, David R. Kearns, Thomas A. Early, Thomas A. Early, Erik Selsing, Erik Selsing, Robert D. Wells, Robert D. Wells   +7 more
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Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V. E. Khutorsky, V. I. Poltev
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Antimicrobials that affect the synthesis and conformation of nucleic acids [PDF]

Revue Scientifique et Technique de l'OIE, 2012
Several antimicrobials act by inhibiting the synthesis of nucleic acids (rifamycins, sulfamides, diaminopyridines), modifying their conformation (quinolones, coumarins) or causing irreversible lesions (nitroimidazoles, nitrofurans). The resistance mechanisms are: a reduction in intracytoplasmic accumulation, modification of the target or the production
T Guillard, E Cambau
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