Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4 [PDF]
, 2006 The genome of bacteriophage T4 encodes three polynucleotide ligases, which seal the backbone of nucleic acids during infection of host bacteria. The T4Dnl (T4 DNA ligase) and two RNA ligases [T4Rnl1 (T4 RNA ligase 1) and T4Rnl2] join a diverse array of ...
Amitsur +61 more
core +5 more sources
Conformational analysis of nucleic acids revisited: Curves+ [PDF]
Nucleic Acids Research, 2009 We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it ...
Lavery, R. +4 more
openaire +3 more sources
Protein-DNA interactions: statistical analysis of interatomic contacts in major and minor grooves
Вавиловский журнал генетики и селекции, 2018 The interactions between protein and DNA in essence underlie all processes in a living cell. Understanding the principles of specific recognition of DNA sites will open the way to understand how these processes are controlled and to interfere in their ...
A. A. Anashkina +5 more
doaj +1 more source
Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. [PDF]
, 2006 The archaeal/eukaryotic proliferating cell nuclear antigen (PCNA) toroidal clamp interacts with a host of DNA modifying enzymes, providing a stable anchorage and enhancing their respective processivities.
Andrew S. Doré +48 more
core +4 more sources
New Journal of Physics, 2013 We have observed the conformation-dependent electronic coupling between the monomeric subunits of a dinucleotide of 2-aminopurine (2-AP), a fluorescent analogue of the nucleic acid base adenine.
Julia R Widom +3 more
doaj +1 more source
Insights on the DNA Stability in Aqueous Solutions of Ionic Liquids
Frontiers in Bioengineering and Biotechnology, 2020 Deoxyribonucleic acid (DNA) carries the genetic information essential for the growth and functioning of living organisms, playing a significant role in life sciences research.
Teresa B. V. Dinis +2 more
doaj +1 more source
Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]
, 2011 We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
Buckley, A. +5 more
core +3 more sources
High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors [PDF]
, 2020 The vast majority of organisms possess transcription elongation factors, the functionally similar bacterial Gre and eukaryotic/archaeal TFIIS/TFS. Their main cellular functions are to proofread errors of transcription and to restart elongation via ...
James, Katherine +2 more
core +2 more sources
T7 RNA polymerase functions in vitro without clustering. [PDF]
PLoS ONE, 2012 Many nucleic acid polymerases function in clusters known as factories. We investigate whether the RNA polymerase (RNAP) of phage T7 also clusters when active.
Kieran Finan +3 more
doaj +1 more source
Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]
, 2009 The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Güntert, Peter +13 more
core +2 more sources