Results 41 to 50 of about 205,585 (348)

Stacking-induced fluorescence increase reveals allosteric interactions through DNA [PDF]

, 2018
From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics. Here we take advantage of the environment-sensitive photoisomerization of cyanine dyes to probe local and ...
Lopez, Sergio G., Magennis, Steven W., Morten, Michael J., Rafferty, Aidan, Steinmark, I. Emilie   +4 more
core   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Model-guided design of ligand-regulated RNAi for programmable control of gene expression [PDF]

, 2008
Progress in constructing biological networks will rely on the development of more advanced components that can be predictably modified to yield optimal system performance.
Chase L Beisel, Christina D Smolke, Kevin G Hoff, Koch AL, Travis S Bayer   +4 more
core   +5 more sources

Methylation Effects on Nucleic Acid Conformations [PDF]

, 1978
Chemical modification of nucleic acids by alkylating agents continues to be extensively explored from the perspective of chemical mutagenesis and carcinogenesis. Largely through the pioneering in vitro and in vivo studies of Lawley (1961), Lawley and Brookes (1963), Singer (1972), and Reese and coworkers (1965), coupled with theoretical predictions of ...
Danyluk, S.S., Ainsworth, C.F., MacCoss, M.   +2 more
openaire   +1 more source

Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions

Journal of Nucleic Acids, 2011
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano, Masayuki Fujii, Naoki Sugimoto   +2 more
doaj   +1 more source

Lone Pair…π Contacts and Structure Signatures of r(UNCG) Tetraloops, Z-Turns, and Z-Steps: A WebFR3D Survey

Molecules, 2022
Z-DNA and Z-RNA have long appeared as oddities to nucleic acid scientists. However, their Z-step constituents are recurrently observed in all types of nucleic acid systems including ribosomes.
Craig L. Zirbel, Pascal Auffinger
doaj   +1 more source

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability

ChemistryOpen, 2022
Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers selected for specific binding functions and have potential applications in medicine and biotechnology.
Elaina P. Boyle, Dr. Levan Lomidze, Prof. Dr. Karin Musier‐Forsyth, Prof. Dr. Besik Kankia   +3 more
doaj   +1 more source

Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. [PDF]

, 2016
RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.
Chong, Jenny, Huang, Xuhui, Hwang, Candy S, Kool, Eric T, McKenna, Charles E, Shin, Ji Hyun, Ulrich, Sébastien, Wang, Dong, Wang, Wei, Xu, Liang, Zhang, Lu   +10 more
core   +3 more sources

Introduction to protein folding for physicists [PDF]

, 2007
The prediction of the three-dimensional native structure of proteins from the knowledge of their amino acid sequence, known as the protein folding problem, is one of the most important yet unsolved issues of modern science.
Abagyan R. A., Arnold V. I., Calera C. Gómez-Moreno, Chothia C., Creighton T. E., Dawkins R., Dawkins R., Drenth J., Dubrovin B. A., Fersht A., Gibson G., Goldstein H., Greiner W., Halgren T. A., Haltia T., Head-Gordon T., Lesk A. M., Levinthal C., Pablo Echenique, Plotkin S. S., Smith C., van Kampen N. G.   +21 more
core   +3 more sources