Results 121 to 130 of about 323,426 (336)
DNA unwinding component of the nonhistone chromatin proteins [PDF]
, 1976 A subclass of nonhistone chromatin proteins from rat liver, previously shown to exhibit high affinity for DNA, has been fractionated by single-stranded DNA-agarose affinity chromatography.
Patel, Gordhan L., Thomas, Terry L.
core
Internal Phase Separation in Synthetic DNA Condensates
Advanced Science, EarlyView.The modular, programmable system of DNA nanostructures developed provides programmatic control over multiphase condensate behavior, enabling mapping onto a predictive Flory‐Huggins model. This combined experimental and theoretical framework will help address open questions in condensate biophysics and facilitate the rational design of functional ...
Diana A. Tanase +5 more
wiley +1 more source
Putative DNA G-quadruplex formation within the promoters of
BMC Genomics, 2009 Background Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can downregulate gene expression, possibly by blocking the ...
Rowe J +7 more
doaj +1 more source
Advanced Science, EarlyView.This review combines the current status of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)‐based molecular diagnostic technology to expound the necessity and challenges faced in promoting the development of one‐pot detection. Besides, the focus is on a comprehensive summary and incisive analysis of emerging strategies for one‐pot ...
Hongyan Liu +10 more
wiley +1 more source
Advanced Science, EarlyView.The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu +19 more
wiley +1 more source
Development of a Conventional Reverse Transcription-PCR System for Broad Detection of Bovine Rhinitis A Virus. [PDF]
Vet Med SciAmplified genome using RT‐PCR with the new primer pair. ABSTRACT Bovine rhinitis A virus (BRAV) is a virus of the genus Aphthovirus, family Picornaviridae. BRAV has recently attracted interest as a causative agent in bovine respiratory disease complex (BRDC).
Koizumi S, Nishi T, Morioka K, Fukai K.
europepmc +2 more sources
Evaluation of protein surface roughness index using its heat denatured aggregates [PDF]
, 2009 Recent research works on potential of different protein surface describing parameters to predict protein surface properties gained significance for its possible implication in extracting clues on protein's functional site. In this direction, Surface
Hrishikesh Mishra, Tapobrata Lahiri
core +1 more source
A two-step method for identifying photopigment opsin and rhodopsin gene sequences underlying human color vision phenotypes. [PDF]
, 2020 PurposeTo present a detailed, reliable long range-PCR and sequencing (LR-PCR-Seq) procedure to identify human opsin gene sequences for variations in the long wavelength-sensitive (OPN1LW), medium wavelength-sensitive (OPN1MW), short wavelength-sensitive (
Atilano, Shari R +3 more
core +1 more source
Advanced Science, EarlyView.Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei +10 more
wiley +1 more source
Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. [PDF]
, 2006 A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness.
Blackburn, Brian G +13 more
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