Results 111 to 120 of about 67,253 (293)
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
, 2015 Oligonucleotides modified with conformationally restricted nucleotides such as locked nucleic acid (LNA) monomers are used extensively in molecular biology and medicinal chemistry to modulate gene expression at the RNA level.
Bharat Baral (27019) +8 more
core +1 more source
Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley +1 more source
Exploring the folding and assembly of nucleic acids by thermal denaturation
, 2018 Nucleic acids are highly dynamic biomolecules that regulate biological function and are widely used to construct nanoscale materials. Nucleic acid folding and assembly dynamics modulate how they interact with the environment to achieve specific molecular
Harkness, Robert
core
Synthesis and Properties of Nucleic Acid Analogues Consisting of a Benzene−Phosphate Backbone
, 2016 The synthesis and properties of a nucleic acid analogue consisting of a benzene−phosphate backbone are described. The building blocks of the nucleic acid analogue are composed of bis(hydroxymethyl)benzene residues connected to nucleobases via the biaryl ...
Aya Shibata (1907263) +8 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu +4 more
wiley +1 more source
Limnology and Oceanography: Methods, EarlyView.Abstract Assigning taxonomic identity and thus assessing taxonomic diversity in gelatinous zooplankton is challenging due to their fragility and difficult preservation. Formalin fixation compromises DNA integrity, while flash‐freezing, ethanol, and acetone preservation affect morphological features. In this study, we developed a methodological protocol
Claudia Traboni +4 more
wiley +1 more source
Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
, 2014 Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases.
Patel, Pradeepkumar L.
core
Synthesis of aromatic peptide nucleic acids [PDF]
, 1999 The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties ...
Boyd, Michael J
core
Nanopore Sequencing for HPV in Oropharyngeal Squamous Cell Carcinoma and Benign Tonsil Specimens
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objectives Human papillomavirus (HPV) accounts for the majority of oropharyngeal squamous cell carcinoma (OPSCC) cases in the United States but understanding the prevalence of high‐risk HPV in oropharyngeal tissue remains poor. We evaluated nanopore sequencing, a novel rapid, and long‐read sequencing platform, on OPSCC tissue and tested it in ...
Mikayla G. Hubbard +5 more
wiley +1 more source
Pediatric Discovery, EarlyView.This cohort study of 395 children (mean age 7 years) with SARS‐CoV‐2 demonstrates that measuring levels of miR‐296‐5p in saliva at the time of initial clinical presentation may aid the prognosis of severe symptoms. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may impact immune‐related micro ribonucleic acids (miRNAs).
Steven D. Hicks +7 more
wiley +1 more source