Results 221 to 230 of about 252,695 (308)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Integrated horizontal convective PCR system for clinical diagnostics. [PDF]

Sci Adv
Guo W, Xu M, Tao Y, Liu W, Zhou H, Guan X, Yang R, Ge Z, Xue R, Zhang Z, Zhou H, Ren Y.   +11 more
europepmc   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Development and validation of a sensitive fluorescence RT-qPCR assay with TaqMan-MGB probe for detection of H6 subtype avian influenza A virus. [PDF]

J Vet Diagn Invest
Li X, Tian J, Zhou W, Liu S, Peng C, Li J, Hou G, Yang J, Liu X, Liu H, Jiang W.   +10 more
europepmc   +1 more source

Universal Regulation of DNA Polymerase via Photocaged Primer Enables Light‐Start Isothermal Amplification on Demand

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing, Yufan Qin, Zhijin Li, Xiufang Yu, Jianbo Wang, Xiaoqiong Liu, Xin Chen, Chao Yu   +7 more
wiley   +1 more source

CtMYB1 regulates flavonoid biosynthesis in safflower flower by binding the CAACCA elements. [PDF]

PLoS One
Zhou Y, Wang J, Peng Y, Chen C, Xian B, Xi Z, Ren C, Pei J, Chen J.   +8 more
europepmc   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Structure and function of the nairovirus cap-snatching endonuclease. [PDF]

Nucleic Acids Res
Kuang W, Tian Z, Zhang G, Wu F, Li J, Tang J, Zhang H, Zhuo X, Hu Z, Wang M, Zhao H, Deng Z.   +11 more
europepmc   +1 more source

Proteome-Wide Monitoring of Drug Action in Living Cells Using a Novel Label-Free Solvent-Based Shift Assay. [PDF]

Mol Cell Proteomics
Steinbrunn D, Cepeleaga C, Betz A, Kibar G, Holzner M, Maier SK, Zasada C, Hagemann G, Sieber SA, Hahne H.   +9 more
europepmc   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source