Results 31 to 40 of about 135,191 (164)
A Global Nucleic Acid Observatory for Biodefense and Planetary Health [PDF]
arXiv, 2021 The spread of pandemic viruses and invasive species can be catastrophic for human societies and natural ecosystems. SARS-CoV-2 demonstrated that the speed of our response is critical, as each day of delay permitted exponential growth and dispersion of the virus.
arxiv
Microbiota of Tayohounta, a fermented baobab flavour food of Benin [PDF]
, 2011 The present work provides data on the microbial composition of Tayohounta, a product of natural fermentation of baobab seed kernels. Samples were collected from 3 different small scale producers from Benin at the end of the fermentation process ...
Chadare, F.J. +5 more
core +2 more sources
Rigid Base Biasing in Molecular Dynamics enables enhanced sampling of DNA conformations [PDF]
arXiv, 2022 All-atom simulations have become increasingly popular to study conformational and dynamical properties of nucleic acids as they are accurate and provide high spatial and time resolutions. This high resolution however comes at a heavy computational cost and within the time scales of simulations nucleic acids weakly fluctuate around their ideal structure
arxiv
Homochirality through Photon-Induced Melting of RNA/DNA: the Thermodynamic Dissipation Theory of the Origin of Life [PDF]
, 2010 The homochirality of the molecules of life has been a vexing problem with no generally accepted solution to date. Since a racemic mixture of chiral nucleotides frustrates the extension and replication of RNA and DNA, understanding the origin of ...
Karo Michaelian
core +2 more sources
Velocity and processivity of helicase unwinding of double-stranded nucleic acids [PDF]
Journal of Physics: Condensed Matter 17 (2005) S3851--S3869, 2005 Helicases are molecular motors which unwind double-stranded nucleic acids (dsNA) in cells. Many helicases move with directional bias on single-stranded (ss) nucleic acids, and couple their directional translocation to strand separation. A model of the coupling between translocation and unwinding uses an interaction potential to represent passive and ...
arxiv +1 more source
Halogen Bonding in Nucleic Acid Complexes [PDF]
, 2017 Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has been gathered about X-bonds in protein-ligand complexes, as opposed to nucleic acid complexes. Here
arxiv +1 more source
Can we model DNA at the mesoscale ? Comment on: Fluctuations in the DNA double helix: A critical review [PDF]
, 2014 Comment on "Fluctuations in the DNA double helix: A critical review" by Frank-Kamenetskii and ...
Dauxois, Thierry, Peyrard, Michel
core +4 more sources
Causal Discovery for Gene Regulatory Network Prediction [PDF]
arXiv, 2023 Biological systems and processes are networks of complex nonlinear regulatory interactions between nucleic acids, proteins, and metabolites. A natural way in which to represent these interaction networks is through the use of a graph. In this formulation, each node represents a nucleic acid, protein, or metabolite and edges represent intermolecular ...
arxiv
Mesoscopic modeling for nucleic acid chain dynamics [PDF]
Phys. Rev. E, 71 art. num. 051902 (2005), 2005 To gain a deeper insight into cellular processes such as transcription and translation, one needs to uncover the mechanisms controlling the configurational changes of nucleic acids. As a step toward this aim, we present here a novel mesoscopic-level computational model that provides a new window into nucleic acid dynamics.
arxiv +1 more source
Twist/Writhe Partitioning in a Coarse-Grained DNA Minicircle Model
, 2009 Here we present a systematic study of supercoil formation in DNA minicircles under varying linking number by using molecular dynamics simulations of a two-bead coarse-grained model. Our model is designed with the purpose of simulating long chains without
Alkan Kabakçıoğlu +3 more
core +1 more source