Results 11 to 20 of about 261,306 (113)

DNA Sensing with Whispering Gallery Mode Microlasers [PDF]

arXiv
Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecu-lar biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers.
Caixeiro S, Dörrenhaus R, Popczyk A, Schubert M, Kath-Schorr S, Gather MC.   +5 more
arxiv   +2 more sources

Secondary structure formation of homopolymeric single-stranded nucleic acids including force and loop entropy: implications for DNA hybridization [PDF]

arXiv, 2011
Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m, we study homopolymeric single-stranded nucleic acid chains under external force and varying ...
Einert, Thomas R., Netz, Roland R., Orland, Henri   +2 more
arxiv   +3 more sources

Crosslinker-modified nucleic acid probes for improved target identification and biomarker detection [PDF]

, 2021
Understanding the intricate interaction pattern of nucleic acids with other molecules is essential to gain further insight in biological processes and disease mechanisms. To this end, a multitude of hybridization-based assays have been designed that rely
Elskens, Joke, Madder, Annemieke
core   +1 more source

Thermodynamic framework to assess low abundance DNA mutation detection by hybridization [PDF]

, 2017
The knowledge of genomic DNA variations in patient samples has a high and increasing value for human diagnostics in its broadest sense. Although many methods and sensors to detect or quantify these variations are available or under development, the ...
Hadiwikarta, Wahyu Wijaya, Hooyberghs, Jef, Jacobs, An, Valkenborg, Dirk, Van Roy, Nadine, Vandesompele, Jo, Venken, Tom, Willems, Hanny   +7 more
core   +8 more sources

Detection of fluorescence in situ hybridization on human metaphase chromosomes by near-field scanning optical microscopy [PDF]

, 1995
Fluorescence in situ hybridization signals o­n human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments o­n a single ...
Jalocha, A., Jalocha, A., Moers, M.H.P., Moers, M.H.P., Ruiter, A.G.T., van Hulst, N.F.   +5 more
core   +6 more sources

Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]

, 2013
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot, A. E. Pozhitkov, A. Halperin, A. Harrison, A. Ott, Amend, B. M. Pettitt, Berger, Binder, Binder, Binder, Binder, Bolstad, Bullard, Burden, Burden, C. Gibas, C. J. Burden, Chou, Chou, Czypionka, D. P. Kreil, D. Tautz, E. Carlon, Fasold, Fasold, Fiche, Fuchs, H. Binder, Halperin, Harr, Harrison, He, Heim, Held, Hooyberghs, Huettel, Iltumur, Irizarry, Irizarry, Irizarry, Irving, J. Hooyberghs, Kane, L. J. Gamble, Lee, Lee, Letowski, Li, Liebich, Lockhart, Luebke, Marshall, Matveeva, Mueckstein, Mulders, Naiser, Naiser, P. A. Noble, Pingel, Pozhitkov, R. Levicky, Relogio, Rouillard, Tanaka, Trapp, Upton, Vainrub, Wodicka, Yu, Zhang   +70 more
core   +3 more sources

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]

, 2015
Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F, Braeckmans, Kevin, Dakwar, George, De Smedt, Stefaan, Figueiredo, Céu, Fontenete, Silvia, Forier, Katrien, Guimarães, Nuno, Leite, Marina, Remaut, Katrien, Santos, Rita, Stremersch, Stephan, Wengel, Jesper, Xiong, Ranhua   +13 more
core   +5 more sources

European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development [PDF]

, 2023
In situ hybridization (ISH) is used for the localization of specific nucleic acid sequences in cells or tissues by complementary binding of a nucleotide probe to a specific target nucleic acid sequence.
Frisk, Anna-Lena, Kreutzer, Robert, Lemarchand, Thomas, Lezmi, Stephane, Monné Rodríguez, Josep M, Saravanan, Chandrassegar, Schaudien, Dirk, Stierstorfer, Birgit, Thuilliez, Céline, Vezzali, Enrico, Wieczorek, Grazyna, Yun, Seong-Wook   +11 more
core   +1 more source

Complex Nucleic Acid Hybridization Reactions inside Capillary-Driven Microfluidic Chips [PDF]

, 2020
Nucleic acid hybridization reactions play an important role in many (bio)chemical fields, for example, for the development of portable point‐of‐care diagnostics, and often such applications require nucleic acid‐based reaction systems that ideally run ...
Delamarche, Emmanuel, Hu, Yong, Niemeyer, Christof M., Rocca, Marco, Salva, Marie L.   +4 more
core   +2 more sources

Electrochemical Characterization of Regularly-aligned Nanopore Array Membranes Filled with Electrolyte Solutions and their use for Detection of Nucleic Acid Hybridization [PDF]

, 2011
We report on the electrochemical characterization of regularlyaligned cylindrical nanopore arrays supported in silicon nitride membranes and preliminary results for the detection of nucleic acid hybridization on the nanopore walls.
Arrigan, Damien, Ellis, J., Glynn, B., Herzog, G.   +3 more
core   +1 more source