Results 51 to 60 of about 437,756 (347)

A New Perspective on the Antimicrobial Mechanism of Berberine Hydrochloride Against Staphylococcus aureus Revealed by Untargeted Metabolomic Studies

open access: yesFrontiers in Microbiology, 2022
Berberine hydrochloride (BBR) is a natural product widely used in clinical medicine and animal production. It has a variety of antimicrobial effects, but its complex antimicrobial mechanism has not been clarified.
Shu Wu   +7 more
doaj   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

open access: yesMolecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source

Therapy of cancer by insect cells containing recombinant baculovirus encoding genes [PDF]

open access: yes, 2002
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that ...
Dhong, Zhongyun   +2 more
core   +1 more source

Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean

open access: yesMolecular Systems Biology, 2014
The reaction sequences of central metabolism, glycolysis and the pentose phosphate pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their evolutionary origins are not yet understood.
Markus A Keller   +2 more
doaj   +1 more source

Defects in germinal center selection in SLE

open access: yesFrontiers in Immunology, 2015
Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and ...
Megan eWoods   +2 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]

open access: yes, 1968
With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core   +1 more source

Shedding light on gene therapy: Carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs - A review

open access: yesJournal of Advanced Research, 2019
Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution.
Reza Mohammadinejad   +8 more
doaj   +1 more source

Identification of precursor transcripts for 6 novel miRNAs expands the diversity on the genomic organisation and expression of miRNA genes in rice [PDF]

open access: yes, 2008
The plant miRNAs represent an important class of endogenous small RNAs that guide cleavage of an mRNA target or repress its translation to control development and adaptation to stresses.
Bangratz, Martine   +15 more
core   +1 more source

Nucleic Acid Precursor Requirements of Mycoplasma laidlawii

open access: yesJournal of General Microbiology, 1962
SUMMARY: The nucleic acid precursor requirements of Mycoplasma laidlawii strain A were determined by using a partially defined medium. Adenine, guanosine and cytidine were found to be the minimal growth requirements. However, best growth was obtained with undegraded RNA or oligoribo-nucleotides.
openaire   +2 more sources

Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation

open access: yesMetabolites, 2017
Proteolysis is essential for all living organisms to maintain the protein homeostasis and to adapt to changing environmental conditions. ClpP is the main protease in Bacillus subtilis, and forms complexes with different Clp ATPases.
Daniel Schultz   +3 more
doaj   +1 more source

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