Results 11 to 20 of about 10,335 (179)
Expression of Nucleolin Affects Microtubule Dynamics.
PLoS ONE, 2016 Nucleolin is present in diverse cellular compartments and is involved in a variety of cellular processes from nucleolar structure and function to intracellular trafficking, cell adhesion and migration. Recently, nucleolin has been localized at the mature
Xavier Gaume +5 more
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Science-Business eXchange, 2011 Nucleolin is a multifunctional phosphoprotein ubiquitously distributed in the nucleolus, nucleus and cytoplasm of the cell. Nucleolin has a bipartite nuclear localization signal sequence and is conserved in animals, plants and yeast. Its levels are correlated with the rate of functional activity of the nucleolus in exponentially growing cells ...
Marjan M, Tajrishi +2 more
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Nucleolin Interacts with Telomerase [PDF]
Journal of Biological Chemistry, 2004 Telomerase is a specialized reverse transcriptase composed of core RNA and protein subunits which plays essential roles in maintaining telomeres in actively dividing cells. Recent work indicates that telomerase shuttles between subcellular compartments during assembly and in response to specific stimuli.
Khurts, Shilagardi +8 more
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Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation [PDF]
Molecular and Cellular Biology, 2002 We recently discovered that heat shock causes nucleolin to relocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DNA replication initiation. We report that nucleolin mobilization also occurs following exposure to ionizing radiation (IR) and treatment with camptothecin. Mobilization was selective in that
Yaron, Daniely +2 more
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AS1411 Nucleolin-Specific Binding Aptamers Reduce Pathological Angiogenesis through Inhibition of Nucleolin Phosphorylation [PDF]
International Journal of Molecular Sciences, 2021 Proliferative retinopathies produces an irreversible type of blindness affecting working age and pediatric population of industrialized countries. Despite the good results of anti-VEGF therapy, intraocular and systemic complications are often associated after its intravitreal use, hence novel therapeutic approaches are needed.
Emilio Iturriaga-Goyon +9 more
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Cloning and sequencing of the human nucleolin cDNA [PDF]
FEBS Letters, 1989 A cDNA containing the entire coding region for human nucleolin has been isolated from a λ gt10 human retinal library using a bovine cDNA probe. The cDNA hybridized to a transcript of 3000 bases from fast‐dividing cells, as well as terminally differentiated tissues of several species.
Srivastava, Meera +3 more
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PLoS ONE, 2013 Nucleolin is implicated to play a role in angiogenesis, a vital process in tumor growth and metastasis. However, the presence and clinical relevance of nucleolin in human non small cell lung cancer (NSCLC) remains largely unknown.
Hongyun Zhao +10 more
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Anti-nucleolin aptamer AS1411: an advancing therapeutic
Frontiers in Molecular Biosciences, 2023 Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Alexander Van den Avont +1 more
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Scientific Reports, 2018 Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano +4 more
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Frontiers in Pharmacology, 2023 Multifunctional nanocarrier platforms have shown great potential for the diagnosis and treatment of liver cancer. Here, a novel nucleolin-responsive nanoparticle platform was constructed for the concurrent detection of nucleolin and treatment of liver ...
Liangliang Xiang +6 more
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