Results 21 to 30 of about 10,335 (179)

Nucleolin and nucleophosmin expression patterns in pulmonary adenocarcinoma invading the pleura and in pleural malignant mesothelioma

Thoracic Cancer, 2020
Background Visceral pleural invasion (VPI) in adenocarcinoma of the lung is considered a poor prognostic factor. The purpose of this study was to analyze nucleolin and nucleophosmin expression in pulmonary adenocarcinoma (PA) with VPI and in pleural ...
Marek Masiuk, Piotr Waloszczyk, Magdalena Lewandowska, Ewa Dobak, Elzbieta Urasinska   +4 more
doaj   +1 more source

Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.

PLoS ONE, 2012
H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA double-strand break (DSB) sites.
Junya Kobayashi, Hiroko Fujimoto, Jun Sato, Ikue Hayashi, Sandeep Burma, Shinya Matsuura, David J Chen, Kenshi Komatsu   +7 more
doaj   +1 more source

RNA-binding protein nucleolin in disease [PDF]

RNA Biology, 2012
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRNA stability and translation, and microRNA processing ...
Kotb, Abdelmohsen, Myriam, Gorospe
openaire   +2 more sources

Host Cell Nucleolin Is Required To Maintain the Architecture of Human Cytomegalovirus Replication Compartments

mBio, 2012
Drastic reorganization of the nucleus is a hallmark of herpesvirus replication. This reorganization includes the formation of viral replication compartments, the subnuclear structures in which the viral DNA genome is replicated.
Blair L. Strang, Steeve Boulant, Tomas Kirchhausen, Donald M. Coen   +3 more
doaj   +1 more source

Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)

Molecules, 2021
Enterovirus 71 (EV-A71) is one of the predominant etiological agents of hand, foot and mouth disease (HMFD), which can cause severe central nervous system infections in young children.
Malihe Masomian, Salima Lalani, Chit Laa Poh   +2 more
doaj   +1 more source

Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.

PLoS ONE, 2014
High concentration of extracellular ADP has been reported to induce cell apoptosis, but the molecular mechanisms remain not fully elucidated. In this study, we found by serendipity that ADP treatment of human umbilical vein endothelial cells (HUVEC) and ...
Wenmeng Wang, Junqing Luo, Fang Xiang, Xueting Liu, Manli Jiang, Lingjuan Liao, Jinyue Hu   +6 more
doaj   +1 more source

Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants

npj Vaccines, 2022
Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and cancers. However, the mechanism by which their cell surface receptors promote their uptake into dendritic cells
Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto, Yasuo Yoshioka   +5 more
doaj   +1 more source

Fine-Tuning of mTOR mRNA and Nucleolin Complexes by SMN

Cells, 2021
Increasing evidence points to the Survival Motor Neuron (SMN) protein as a key determinant of translation pathway. Besides its role in RNA processing and sorting, several works support a critical implication of SMN in ribosome biogenesis.
Francesca Gabanella, Christian Barbato, Marco Fiore, Carla Petrella, Marco de Vincentiis, Antonio Greco, Antonio Minni, Nicoletta Corbi, Claudio Passananti, Maria Grazia Di Certo   +9 more
doaj   +1 more source

Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.

PLoS ONE, 2012
IntroductionThe orphan nuclear receptor COUP-TFII plays an undefined role in breast cancer. Previously we reported lower COUP-TFII expression in tamoxifen/endocrine-resistant versus sensitive breast cancer cell lines.
Lacey M Litchfield, Krista A Riggs, Alyson M Hockenberry, Laura D Oliver, Katelyn G Barnhart, Jian Cai, William M Pierce, Margarita M Ivanova, Paula J Bates, Savitri N Appana, Susmita Datta, Piotr Kulesza, Jean McBryan, Leonie S Young, Carolyn M Klinge   +14 more
doaj   +1 more source

Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

BMC Cancer, 2011
Background Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal RGG domain of nucleolin, the HB-19 pseudopeptide, we ...
Hovanessian Ara G, Soundaramourty Calaiselvy, Nondier Isabelle, El Khoury Diala, Krust Bernard   +4 more
doaj   +1 more source