Results 21 to 30 of about 12,341 (216)

Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma [PDF]

, 2022
Active drug delivery by tumor-targeting peptides is a promising approach to improve existing therapies for rhabdomyosarcoma (RMS), by increasing the therapeutic effect and decreasing the systemic toxicity, e.g., by drug-loaded peptide-targeted ...
De Micheli, Andrea J., Michele Bernasconi, Dzhumashev, Dzhangar, Andrea J. De Micheli, Andrea Timpanaro, Jochen Rössler, Rössler, Jochen K, Mamchaoui, Kamel, Dzhangar Dzhumashev, Ilaria Cascone, Timpanaro, Andrea, Cascone, Ilaria, Bernasconi, Michele, De Micheli, Andrea J, Safa Ali, Ali, Safa, Rössler, Jochen, de Micheli, Andrea, Kamel Mamchaoui   +18 more
core   +1 more source

RNA-binding protein nucleolin in disease [PDF]

RNA Biology, 2012
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRNA stability and translation, and microRNA processing ...
Kotb, Abdelmohsen, Myriam, Gorospe
openaire   +2 more sources

Prognostic significance of the combined score of endothelial expression of nucleolin and CD31 in surgically resected non-small cell lung cancer.

PLoS ONE, 2013
Nucleolin is implicated to play a role in angiogenesis, a vital process in tumor growth and metastasis. However, the presence and clinical relevance of nucleolin in human non small cell lung cancer (NSCLC) remains largely unknown.
Hongyun Zhao, Yan Huang, Cong Xue, Yang Chen, Xue Hou, Ying Guo, Liping Zhao, Zhi huang Hu, Yujie Huang, Yongzhang Luo, Li Zhang   +10 more
doaj   +1 more source

Anti-nucleolin aptamer AS1411: an advancing therapeutic

Frontiers in Molecular Biosciences, 2023
Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Alexander Van den Avont, Neelam Sharma-Walia   +1 more
doaj   +1 more source

Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death.

PLoS ONE, 2013
BackgroundThe ErbB receptors, Ras proteins and nucleolin are major contributors to malignant transformation. The pleiotropic protein nucleolin can bind to both Ras protein and ErbB receptors.
Sari Schokoroy, Dolly Juster, Yoel Kloog, Ronit Pinkas-Kramarski   +3 more
doaj   +1 more source

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

Scientific Reports, 2018
Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano, Vera Moura, Sérgio Simões, João Nuno Moreira, João Gonçalves   +4 more
doaj   +1 more source

Nucleolin and nucleophosmin expression patterns in pulmonary adenocarcinoma invading the pleura and in pleural malignant mesothelioma

Thoracic Cancer, 2020
Background Visceral pleural invasion (VPI) in adenocarcinoma of the lung is considered a poor prognostic factor. The purpose of this study was to analyze nucleolin and nucleophosmin expression in pulmonary adenocarcinoma (PA) with VPI and in pleural ...
Marek Masiuk, Piotr Waloszczyk, Magdalena Lewandowska, Ewa Dobak, Elzbieta Urasinska   +4 more
doaj   +1 more source

Host Cell Nucleolin Is Required To Maintain the Architecture of Human Cytomegalovirus Replication Compartments

mBio, 2012
Drastic reorganization of the nucleus is a hallmark of herpesvirus replication. This reorganization includes the formation of viral replication compartments, the subnuclear structures in which the viral DNA genome is replicated.
Blair L. Strang, Steeve Boulant, Tomas Kirchhausen, Donald M. Coen   +3 more
doaj   +1 more source

Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.

PLoS ONE, 2012
H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA double-strand break (DSB) sites.
Junya Kobayashi, Hiroko Fujimoto, Jun Sato, Ikue Hayashi, Sandeep Burma, Shinya Matsuura, David J Chen, Kenshi Komatsu   +7 more
doaj   +1 more source

Nucleolin recognizing silica nanoparticles inhibit cell proliferation by activating the Bax/Bcl-2/caspase-3 signalling pathway to induce apoptosis in liver cancer

Frontiers in Pharmacology, 2023
Multifunctional nanocarrier platforms have shown great potential for the diagnosis and treatment of liver cancer. Here, a novel nucleolin-responsive nanoparticle platform was constructed for the concurrent detection of nucleolin and treatment of liver ...
Liangliang Xiang, Yun Li, Xinyu Gu, Shujie Li, Junwei Li, Jinlong Li, Yongxiang Yi   +6 more
doaj   +1 more source