Results 31 to 40 of about 12,341 (216)

Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)

Molecules, 2021
Enterovirus 71 (EV-A71) is one of the predominant etiological agents of hand, foot and mouth disease (HMFD), which can cause severe central nervous system infections in young children.
Malihe Masomian, Salima Lalani, Chit Laa Poh   +2 more
doaj   +1 more source

Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

BMC Cancer, 2011
Background Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal RGG domain of nucleolin, the HB-19 pseudopeptide, we ...
Hovanessian Ara G, Soundaramourty Calaiselvy, Nondier Isabelle, El Khoury Diala, Krust Bernard   +4 more
doaj   +1 more source

Fine-Tuning of mTOR mRNA and Nucleolin Complexes by SMN

Cells, 2021
Increasing evidence points to the Survival Motor Neuron (SMN) protein as a key determinant of translation pathway. Besides its role in RNA processing and sorting, several works support a critical implication of SMN in ribosome biogenesis.
Francesca Gabanella, Christian Barbato, Marco Fiore, Carla Petrella, Marco de Vincentiis, Antonio Greco, Antonio Minni, Nicoletta Corbi, Claudio Passananti, Maria Grazia Di Certo   +9 more
doaj   +1 more source

Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.

PLoS ONE, 2012
IntroductionThe orphan nuclear receptor COUP-TFII plays an undefined role in breast cancer. Previously we reported lower COUP-TFII expression in tamoxifen/endocrine-resistant versus sensitive breast cancer cell lines.
Lacey M Litchfield, Krista A Riggs, Alyson M Hockenberry, Laura D Oliver, Katelyn G Barnhart, Jian Cai, William M Pierce, Margarita M Ivanova, Paula J Bates, Savitri N Appana, Susmita Datta, Piotr Kulesza, Jean McBryan, Leonie S Young, Carolyn M Klinge   +14 more
doaj   +1 more source

Roles of nucleolin

Saudi Medical Journal, 2016
Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many modulations including rDNA transcription, RNA metabolism, and ribosome assembly. Nucleolin is also found in the cytoplasm and on the cell membrane, and surface nucleolin can bind to various ligands to affect many physiological functions.
Chen, Zhuo, Xu, XinHua
openaire   +2 more sources

DataSheet1_Anti-nucleolin aptamer AS1411: an advancing therapeutic.PDF

, 2023
Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Alexander Van den Avont (17017158), Neelam Sharma-Walia, Neelam Sharma-Walia (202892), Alexander Van den Avont   +3 more
core   +1 more source

Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.

PLoS ONE, 2014
High concentration of extracellular ADP has been reported to induce cell apoptosis, but the molecular mechanisms remain not fully elucidated. In this study, we found by serendipity that ADP treatment of human umbilical vein endothelial cells (HUVEC) and ...
Wenmeng Wang, Junqing Luo, Fang Xiang, Xueting Liu, Manli Jiang, Lingjuan Liao, Jinyue Hu   +6 more
doaj   +1 more source

Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants

npj Vaccines, 2022
Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and cancers. However, the mechanism by which their cell surface receptors promote their uptake into dendritic cells
Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto, Yasuo Yoshioka   +5 more
doaj   +1 more source

Myogenetic Oligodeoxynucleotides as Anti-Nucleolin Aptamers Inhibit the Growth of Embryonal Rhabdomyosarcoma Cells

Biomedicines, 2022
Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving as anti-nucleolin aptamers, have been reported to inhibit the proliferation and induce
Naoki Nohira, Sayaka Shinji, Shunichi Nakamura, Yuma Nihashi, Takeshi Shimosato, Tomohide Takaya   +5 more
doaj   +1 more source

Integrated analysis of mRNA and miRNA expression in HeLa cells expressing low levels of Nucleolin

Scientific Reports, 2017
Nucleolin is an essential protein that plays important roles in the regulation of cell cycle and cell proliferation. Its expression is up regulated in many cancer cells but its molecular functions are not well characterized.
Sanjeev Kumar, Elizabhet Cruz Gomez, Mounira Chalabi-Dchar, Cong Rong, Sadhan Das, Iva Ugrinova, Xavier Gaume, Karine Monier, Fabien Mongelard, Philippe Bouvet   +9 more
doaj   +1 more source