Results 51 to 60 of about 12,341 (216)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

ADP down-regulates nucleolin protein level.

, 2014
(A) Dose-response. HUVEC were treated with the indicated concentrations of ADP for 72 h. Medium was replaced with fresh medium containing ADP every day. The nucleolin protein was detected by western blot. β-actin protein was detected as a loading control.
Manli Jiang (473858), Fang Xiang (640728), Xueting Liu (473855), Junqing Luo (640727), Lingjuan Liao (640729), Wenmeng Wang (640726), Jinyue Hu (473853)   +6 more
core   +1 more source

Respiratory syncytial virus prolifically infects N2a neuronal cells, leading to TLR4 and nucleolin protein modulations and RSV F protein co-localization with TLR4 and nucleolin

Journal of Biomedical Science, 2018
Background Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated.
Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen, Shenghai Huang   +8 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Nucleolin is an IGFBP-5 binding partner.

, 2015
Following identification of nucleolin using mass spectrometry, interaction with IGFBP-5 was confirmed using co-precipitation. (A) Wild type IGFBP-5 binds nucleolin in fibroblasts from three different donors.
Carol Feghali-Bostwick (270228), Tetsuya Nishimoto (75162), Yunyun Su (144022)   +2 more
core   +1 more source

A novel receptor – ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu

BMC Microbiology, 2008
Background Francisella tularensis, the causative agent of tularemia, is one of the most infectious human bacterial pathogens. It is phagocytosed by immune cells, such as monocytes and macrophages.
Charbit Alain, Dupuis Marion, Briand Jean-Paul, Meibom Karin, Hovanessian Ara G, Barel Monique   +5 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Nucleolin participates in DSB repair.

, 2012
(A) Nucleolin interacts with HR factors, RPA34 and NBS1 in response to DNA damage. The extracts from normal lymphoblastoid cells were immunoprecipitated with anti-nucleolin antibody or normal rabbit IgG, and then the immuno-complexes were detected by ...
Hiroko Fujimoto (122496), Junya Kobayashi (122490), Kenshi Komatsu (122536), Jun Sato (122503), Sandeep Burma (122515), Shinya Matsuura (122522), Ikue Hayashi (122508), David J. Chen (122529)   +7 more
core   +1 more source

Nucleophosmin and nucleolin regulate K-Ras signaling [PDF]

, 2010
Ras proteins are laterally segregated into transient nanoclusters on the plasma membrane, a property essential for high fidelity signal transduction through the MAPK pathway.
John F Hancock, Hancock, John F., Kerry L Inder, Inder, Kerry L., Michelle M Hill, Hill, Michelle M.   +5 more
core   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source