Results 51 to 60 of about 10,335 (179)

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, Volume 22, Issue 43, 3 August 2026.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Stat1 nuclear translocation by nucleolin upon monocyte differentiation.

PLoS ONE, 2009
BackgroundMembers of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized structure, called the nuclear pore complex (NPC), which represents a selective filter for
Uwe Jerke, Sergey Tkachuk, Julia Kiyan, Victoria Stepanova, Angelika Kusch, Michael Hinz, Rainer Dietz, Hermann Haller, Bianca Fuhrman, Inna Dumler   +9 more
doaj   +1 more source

Contrast Agents for Enhanced Bioimaging: A Comprehensive Review

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube, Donald Fernandes, Arthur Abinader Vasconcelos, Hugo de Campos Braga, Alan Kelbis Oliveira Lima, José Arnaldo Santana Costa, Karla Furtado Andriani, Ester da Cunha Meira Santos, Antonio Jorge Silva Araújo Junior, Hauster Maximiler Campos de Paula, Wallace Júnio Reis, Kashif Gul, Nida Wahab, Luis Carlos Resio, Elisa Kawana Leal dos Santos, Márcio Peres de Araujo, Matheus Allen P. da Silva, Juliana Paula da Silva   +17 more
wiley   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, Volume 38, Issue 40, 17 July 2026.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Meeting the needs of breast cancer: A nucleolin’s perspective [PDF]

Critical Reviews in Oncology/Hematology, 2018
A major challenge in the management of breast cancer disease has been the development of metastases. Finding new molecular targets and the design of targeted therapeutic approaches to improve the overall survival and quality of life of these patients is, therefore, of great importance.
Gregório, Ana C., Lacerda, Manuela, Figueiredo, Paulo, Simões, Sérgio, Dias, Sérgio, Moreira, João Nuno   +5 more
openaire   +3 more sources

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, Volume 11, Issue 13, 8 July 2026.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Suppression of tumor growth and angiogenesis by a specific antagonist of the cell-surface expressed nucleolin.

PLoS ONE, 2008
BackgroundEmerging evidences suggest that nucleolin expressed on the cell surface is implicated in growth of tumor cells and angiogenesis. Nucleolin is one of the major proteins of the nucleolus, but it is also expressed on the cell surface where is ...
Damien Destouches, Diala El Khoury, Yamina Hamma-Kourbali, Bernard Krust, Patricia Albanese, Panagiotis Katsoris, Gilles Guichard, Jean Paul Briand, José Courty, Ara G Hovanessian   +9 more
doaj   +1 more source

Nucleolin mediates the antiangiogenesis effect of the pseudopeptide N6L

BMC Cell Biology, 2012
Background Nucleolin is a protein over-expressed on the surface of activated cells. Recent studies have underlined the involvement of cell surface nucleolin in angiogenesis processes.
Birmpas Charalampos, Briand Jean Paul, Courty Josẻ, Katsoris Panagiotis   +3 more
doaj   +1 more source

Tumour‐macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR‐194‐5p promotes NSCLC progression

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
NFIC/METTL3 negative feedback loop in NSCLC cells suppresses exosomal miR‐194‐5p via m6A methylation; reduced miR‐194‐5p deepresses ZNF106 in macrophages, promoting M2 polarization and IL‐6 secretion; Macrophage‐derived IL‐6 activates JAK2/STAT3 in NSCLC cells to upregulate METTL3, forming a positive feedback loop.
Shu Fang, Mingyue Hao, Han Meng, Yuhang Jiang, Qiwen Li, Jiao Liang, Xiaolu He, Yi Hu, Linling Zhou, Qianrun Wang, Qiyuan Zhuo, Ji Wu, Kesong Shi   +12 more
wiley   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, Volume 26, Issue 7, Page 28-41, July 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source