Results 71 to 80 of about 10,335 (179)

Myogenic Anti-Nucleolin Aptamer iSN04 Inhibits Proliferation and Promotes Differentiation of Vascular Smooth Muscle Cells

open access: yesBiomolecules
De-differentiation and subsequent increased proliferation and inflammation of vascular smooth muscle cells (VSMCs) is one of the mechanisms of atherogenesis.
Mana Miyoshi   +2 more
doaj   +1 more source

Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression.

open access: yesPLoS ONE, 2016
Influenza A virus nucleoprotein, is a multifunctional RNA-binding protein, encoded by segment-5 of the negative sense RNA genome. It serves as a key connector between the virus and the host during virus replication.
Deepshikha Kumar   +2 more
doaj   +1 more source

Genomic organization of nucleolin gene in carp fish: Evidence for several genes

open access: yesBiological Research, 2006
The protein nucleolin, functionally involved in the main steps of ribosome biogenesis, is codified by a single copy gene in mammals. Here we report that at least three different genes codify for this protein in carp fish (Cyprinus carpio).
CLAUDIA QUEZADA   +5 more
doaj  

The crosstalk between ErbB1 and nucleolin

open access: yesCommunicative & Integrative Biology, 2009
The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas. Ligand binding to specific ErbB receptor is followed by receptor dimerization, phosphorylation and recruitment of SH2 containing cytoplasmic proteins, which initiate the cascade of ...
Keren Farin, Ronit Pinkas-Kramarski
openaire   +1 more source

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

open access: yesMolecular Oncology, 2015
AS1411 is a G‐rich quadruplex‐forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells.
E. Merit Reyes-Reyes   +4 more
doaj   +1 more source

Identification of nucleolin as new ErbB receptors- interacting protein.

open access: yesPLoS ONE, 2008
BackgroundThe ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni   +2 more
doaj   +1 more source

Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation.

open access: yesPLoS ONE, 2014
AimsPhenformin, resveratrol and AICAR stimulate the energy sensor 5'-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli.
Mohamed Kodiha   +3 more
doaj   +1 more source

电离辐射诱导HepG2细胞中Nucleolin和p53变化时程研究

open access: yesZhongguo shiyan zhenduanxue, 2013
目的检测电离辐射照射HepG2细胞后,其Nucleolin和p53蛋白的变化情况,结果将为进一步揭示电离辐射对p53信号传导通路的影响提供重要的细胞学基础,并为辐射生物效应研究提供新的生物学依据。方法电离辐射照射HepG2细胞后,分别提取总蛋白、胞浆蛋白和胞核蛋白,然后采用流式和Western Blot的方法进行蛋白检测。结果 HepG2细胞接受4Gy电离辐射照射后,其总蛋白中的Nucleolin和p53表达水平增高,且与照射时间呈正相关;HepG2细胞接受电离辐射照射后的2h ...
钟莉莉   +4 more
doaj  

A role for nucleolin in functional improvement in stroke. [PDF]

open access: yesiScience
Bridges SP   +6 more
europepmc   +1 more source

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