Results 21 to 30 of about 72,696 (188)

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Aqueous Two‐Phase Submicron Droplets Catalyze DNA Nanostructure Assembly for Confined Fluorescent Biosensing

Advanced Science, EarlyView.
Submicron droplets, formed by a polyethyleneglycol (PEG)/dextran aqueous two‐phase system·(ATPS), can act as catalytic centers that concentrate DNA and accelerate assembly kinetic in crowded environments. It highlights a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides ...
Xiaoman Duan, Siyi Duan, Zhaoyu Han, Haoyue Lv, Haozhen Yu, Biwu Liu   +5 more
wiley   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +9 more
wiley   +1 more source

The nonstructural protein NSs of Schmallenberg virus is targeted to the nucleolus and induces nucleolar disorganization [PDF]

, 2016
Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European countries. SBV is an orthobunyavirus that causes abortion and congenital abnormalities in ruminants.
Breard, Emmanuel, Caignard, Grégory, Cochet, Marielle, Coulpier, Muriel, Fablet, Aurore, Gouzil, Julie, Kundlacz, Cindy, Lara, Estelle, Palmarini, Massimo, Sailleau, Corinne, Varela, Mariana, Viarouge, Cyril, Vitour, Damien, Zientara, Stéphan   +13 more
core   +2 more sources

Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy

Advanced Science, EarlyView.
Multiple therapeutic modalities combined in a synergistic way that can modulate different immune axes are demonstrated potentially effective in boosting immunotherapy. A nucleic acid‐locked smart carrier (NASC) performed as an “all‐in‐one” nanoplatform is constructed for efficient eliciting chemo‐ and photothermal‐amplified immunogenic cell death to ...
Jiayang Zhang, Tianyu Gai, Jiwei Wang, Yucai Wu, Si‐Ming Zeng, Dongyuan Zhao, Wei Li   +6 more
wiley   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Autofluorescence Imaging and Virtual Histological Staining of Human Prostate Sections for Cancer Diagnosis

Advanced Intelligent Systems, EarlyView.
Autofluorescence imaging with virtual histological staining streamlines postoperative histopathology. Using a deep ultraviolet light‐emitting diode (LED)‐based imaging system and a weakly supervised deep learning model, virtual hematoxylin and eosin (H&E)‐stained images are generated from the autofluorescence of prostate tissue. Pathologist evaluations
Mingxuan Si, Weixing Dai, Ivy H. M. Wong, Yan Zhang, Tony K. F. Ma, Ping Wing Ng, Kwok Hung Li, Sylvia M. S. Wong, John H. K. Ngan, Terence T. W. Wong   +9 more
wiley   +1 more source

1-concave basis for TU games [PDF]

, 2005
The first stage of research, twenty years ago, on the subclass of 1-convex TU games dealt with its characterization through some regular core structure. Appealing abstract and practical examples of 1-convex games were missing until now.
Driessen, T.S.H., Khmelnitskaya, A.B., Sales, J.   +2 more
core   +1 more source

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, Accepted Article.
Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets.
Jonathan Franke, Jan Vincent V. Arafiles, Leis Christian, Christian Hackenberger   +3 more
wiley   +1 more source

Senkyunolide I Improves Septicemia‐Induced Brain Dysfunction via Regulating Nrf2 and Astrocyte Activity.

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley   +1 more source