Results 31 to 40 of about 79,372 (334)
Viral Impact in Autoimmune Diseases: Expanding the “X Chromosome–Nucleolus Nexus” Hypothesis
Frontiers in Immunology, 2017 Viruses are suspected of significant roles in autoimmune diseases but the mechanisms are unclear. We get some insight by considering demands a virus places on host cells. Viruses not only require production of their own proteins, RNA and/or DNA, but also
Wesley H. Brooks
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Nature Communications, 2023 Here the authors developed a nucleolus Hi-C technique (nHi-C) for enriching nucleolus-associated interactions, and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells at high resolution.
Ting Peng +11 more
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On the nucleolus of neighbor games [PDF]
European Journal of Operational Research, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hamers, H.J.M. +4 more
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Cell Reports, 2016 The nucleolus is the site of rRNA gene transcription, rRNA processing, and ribosome biogenesis. However, the nucleolus also plays additional roles in the cell. We isolated nucleoli using fluorescence-activated cell sorting (FACS) and identified nucleolus-
Frédéric Pontvianne +11 more
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PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions
Nature Communications, 2023 The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stress.
Xiaocen Jin +10 more
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Cross-compartment signal propagation in the mitotic exit network
eLife, 2021 In budding yeast, the mitotic exit network (MEN), a GTPase signaling cascade, integrates spatial and temporal cues to promote exit from mitosis. This signal integration requires transmission of a signal generated on the cytoplasmic face of spindle pole ...
Xiaoxue Zhou +3 more
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The Nucleolus under Stress [PDF]
Molecular Cell, 2010 Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover.
Boulon, Severine +4 more
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Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]
, 2017 Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M. +10 more
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Genome Organization in and around the Nucleolus
Cells, 2019 The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal RNA (rRNA) genes.
Cristiana Bersaglieri, Raffaella Santoro
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Nucleolus in the Spotlight [PDF]
Cell Cycle, 2004 The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of
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