Results 131 to 140 of about 23,876 (290)

Specific Nucleoporin Requirement for Smad Nuclear Translocation [PDF]

Molecular and Cellular Biology, 2010
Cytoplasm-to-nucleus translocation of Smad is a fundamental step in transforming growth factor beta (TGF-beta) signal transduction. Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but not the constitutive import of ...
Xiaochu, Chen, Lan, Xu
openaire   +2 more sources

Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.

PLoS ONE, 2014
In actively dividing eukaryotic cells, chromosome ends (telomeres) are subject to progressive shortening, unless they are maintained by the action of telomerase, a dedicated enzyme that adds DNA sequence repeats to chromosomal 3'end.
Cornelia Frohnert, Saskia Hutten, Sarah Wälde, Annegret Nath, Ralph H Kehlenbach   +4 more
doaj   +1 more source

Nucleoporin mediated nuclear positioning and silencing of HMR. [PDF]

PLoS ONE, 2011
The organization of chromatin domains in the nucleus is an important factor in gene regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear periphery while transcriptionally poised chromatin resides in the nuclear ...
Giulia J Ruben, Jacob G Kirkland, Tracy MacDonough, Miao Chen, Rudra N Dubey, Marc R Gartenberg, Rohinton T Kamakaka   +6 more
doaj   +1 more source

Architecture of the fungal nuclear pore inner ring complex [PDF]

, 2015
The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kDa inner ring complex (IRC), which forms the central transport channel ...
Bley, Christopher J., Collins, Leslie N., Fischer, Jessica, Hoelz, André, Huber, Ferdinand M., Hurt, Ed, Jeon, Young E., Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A., Lin, Daniel H., Lu, Vincent, Paduch, Marcin, Petrovic, Stefan, Rundlet, Emily J., Stuwe, Tobias, Thierbach, Karsten   +16 more
core   +1 more source

Nucleoporin Nup155 is part of the p53 network in liver cancer

Nature Communications, 2019
Cancer-relevant signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear pore complex (NPC). However, mechanisms by which individual NPC components (Nups) participate in the regulation of these pathways remain ...
K. Holzer, A. Ori, A. Cooke, D. Dauch, E. Drucker, P. Riemenschneider, A. Andres-Pons, Amanda L. DiGuilio, Marie-Therese Mackmull, J. Baßler, S. Roessler, K. Breuhahn, L. Zender, J. Glavy, F. Dombrowski, E. Hurt, P. Schirmacher, Martin Beck, S. Singer   +18 more
semanticscholar   +1 more source

Mutations in Components of the TREX‐2 Complex Result in Misexpression of the Kelch‐Domain F‐Box Protein KFB39 Promoter in Arabidopsis thaliana

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Arabidopsis thaliana gene At2g44130 encodes a Kelch‐like domain F‐box protein designated KFB39 and was previously shown to be specifically expressed on exposure to the oxylipin cis‐jasmone. In order to better understand the regulation of At2g44130, a forward genetic screen was carried out to identify mutants in which a promoter‐GUS fusion was ...
Michaela C. Matthes, Smita Kurup, John A. Pickett, Johnathan A. Napier   +3 more
wiley   +1 more source

A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

Nature Communications, 2018
The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering ...
Jérôme O. Rouvière, Manuel Bulfoni, Alex Tuck, Bertrand Cosson, Frédéric Devaux, Benoit Palancade   +5 more
doaj   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity [PDF]

Cell, 2002
Posttranslational modification with SUMO1 regulates protein/protein interactions, localization, and stability. SUMOylation requires the E1 enzyme Aos1/Uba2 and the E2 enzyme Ubc9. A family of E3-like factors, PIAS proteins, was discovered recently. Here we show that the nucleoporin RanBP2/Nup358 also has SUMO1 E3-like activity.
Pichler, Andrea, Gast, Andreas, Seeler, Jacob-Sebastian, Dejean, Anne, Melchior, Frauke   +4 more
openaire   +3 more sources

A comparison between nuclear dismantling during plant and animal programmed cell death [PDF]

, 2012
Programmed cell death (PCD) is a process of organized destruction of cells, essential for the development and maintenance of cellular homeostasis of multicellular organisms.
Cejudo Fernández, Francisco Javier, Domínguez del Toro, Fernando   +1 more
core   +1 more source