Results 151 to 160 of about 23,876 (290)

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Liquid–liquid phase separation (LLPS) has emerged as a critical mechanism underlying oncogenic signaling and transcriptional regulation; however, its involvement in triple‐negative breast cancer (TNBC) remains largely unknown.
Min Zhang, Chanjin Liang, Ting Chen, Xingyuan Shi, Jiqing Hao   +4 more
wiley   +1 more source

Compensation for chronic oxidative stress in ALADIN null mice

Biology Open, 2018
Mutations in the AAAS gene coding for the nuclear pore complex protein ALADIN lead to the autosomal recessive disorder triple A syndrome. Triple A patients present with a characteristic phenotype including alacrima, achalasia and adrenal insufficiency ...
Ramona Jühlen, Mirko Peitzsch, Sebastian Gärtner, Dana Landgraf, Graeme Eisenhofer, Angela Huebner, Katrin Koehler   +6 more
doaj   +1 more source

Seh1 targets GATOR2 and Nup153 to mitotic chromosomes [PDF]

, 2018
In metazoa the Nup107-160 nucleoporin Y complex plays a major role in formation of the nuclear pore complex in interphase and is localised to kinetochores in mitosis.
Earnshaw, W C, Kanemaki, Masato T, Platani, Melpomeni, Samejima, Itaru, Samejima, Kumiko   +4 more
core   +1 more source

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease

Nucleus
Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures ...
Junyan Lin, Izabela Sumara
doaj   +1 more source

The Multiple Faces of Disordered Nucleoporins

Journal of Molecular Biology, 2016
An evolutionary advantage of intrinsically disordered proteins (IDPs) is their ability to bind a variety of folded proteins-a paradigm that is central to the nucleocytoplasmic transport mechanism, in which nuclear transport receptors mediate the translocation of various cargo through the nuclear pore complex by binding disordered phenylalanine-glycine ...
openaire   +2 more sources

Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers

Cell Division, 2018
Background Membrane-associated progesterone receptors are restricted to the endoplasmic reticulum and are shown to regulate the activity of cytochrome P450 enzymes which are involved in steroidogenesis or drug detoxification.
Ramona Jühlen, Dana Landgraf, Angela Huebner, Katrin Koehler   +3 more
doaj   +1 more source

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core   +1 more source

Crystallographic and Biochemical Analysis of the Ran-Binding Zinc Finger Domain [PDF]

, 2009
The nuclear pore complex (NPC) resides in circular openings within the nuclear envelope and serves as the sole conduit to facilitate nucleocytoplasmic transport in eukaryotes.
Adams, Alam, Alber, Ball, Banatao, Bastos, Boehmer, Chook, Cook, Cooper, Crooks, D'Angelo, Denning, Dimaano, Edgar, Emsley, Fahrenkrog, Gamsjaeger, Gorlich, Higa, Hulo, James R. Partridge, Joseph, Kiseleva, Kiseleva, Krull, Laskowski, Lim, Loughlin, Matsuura, Meier, Mizutani, Nakielny, Otwinowski, Pante, Pichler, Ribbeck, Ribbeck, Salina, Schneider, Schrader, Schwartz, Shah, Shah, Stewart, Stewart, Sukegawa, Thomas U. Schwartz, Tran, Ullman, Vetter, Walther, Walther, Wang, Waterhouse, Weis, Wu, Yaseen, Yokoyama, Yu   +59 more
core   +1 more source

Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities

Nature Cell Biology, 2022
Sarah M. Prophet, Anthony J. Rampello, Robert F. Niescier, Juliana E. Gentile, Sunanda Mallik, A. Koleske, Christian Schlieker   +6 more
semanticscholar   +1 more source