Results 191 to 200 of about 6,849 (214)
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From nucleoporins to nuclear pore complexes
Current Opinion in Cell Biology, 1997One of the largest supramolecular assemblies in the eukaryotic cell, the nuclear pore complex, is now being dissected into its numerous molecular constituents. The combined use of biochemistry and genetics in yeast has made this rapid development possible.
V, Doye, E, Hurt
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Modeling the nucleoporins that form the hairy pores
Biochemical Society Transactions, 2020Sitting on the nuclear envelope, nuclear pore complexes (NPCs) control the molecular transport between the nucleus and the cytoplasm. Without definite open or close states, the NPC uses a family of intrinsically disordered nucleoporins called FG-Nups to construct a selective permeability barrier whose functional structure is unclear.
Kai Huang, Igal Szleifer
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Across the nuclear pores with the help of nucleoporins
Chromosoma, 1991Proteins targeted to specific intracellular organelles such as mitochondria or the endoplasmic reticulum are able to cross membranes. Yet, to enter or exit the nucleus, proteins and RNA must pass through nonmembranous "gates" of the nuclear envelope, the nuclear pore complexes.
M, Carmo-Fonseca, E C, Hurt
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Nucleoporins and nucleocytoplasmic transport in hematologic malignancies
Seminars in Cancer Biology, 2014Hematologic malignancies are often associated with chromosomal rearrangements that lead to the expression of chimeric fusion proteins. Rearrangements of the genes encoding two nucleoporins, NUP98 and NUP214, have been implicated in the pathogenesis of several types of hematologic malignancies, particularly acute myeloid leukemia.
Akiko, Takeda, Nabeel R, Yaseen
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Roles of the Nucleoporin Tpr in Cancer and Aging
2014Tpr is a prominent architectural component of the nuclear pore complex that forms the basket-like structure on the nucleoplasmic side of the pore. Tpr, which stands for translocated promoter region, was originally described in the context of oncogenic fusions with the receptor tyrosine kinases Met, TRK, and Raf.
Chelsi J, Snow, Bryce M, Paschal
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Prevalence and Functionality of Intrinsic Disorder in Human FG-Nucleoporins
International Journal of Biological Macromolecules, 2021Timir Tripathi +2 more
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Gene Silencing During Oocyte Specification Requires Heterochromatin and Nucleoporins
Nature Reviews Molecular Cell Biology, 2023Lisa Heinke
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