Results 1 to 10 of about 101,993 (329)

Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions [PDF]

Journal of Virology, 2018
The genome of influenza A virus is organized into eight viral ribonucleoproteins (vRNPs); this provides evolutionary advantages but complicates genome packaging.
Hardin Bolte, Miruna E. Rosu, Elena Hagelauer, Adolfo Garcı́a-Sastre, Martin Schwemmle   +4 more
openalex   +2 more sources

Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein

Frontiers in Microbiology, 2019
Human parainfluenza virus type 3 (HPIV3) is one of the primary pathogens that causing severe respiratory tract diseases in newborns and infants. It could induce inclusion bodies (IBs) in infected cells.
Yinshuang Li, Yinshuang Li, Chaoliang Zhang, Chaoliang Zhang, Nan Lu, Xichuan Deng, Guangchao Zang, Shengwei Zhang, Hong Tang, Guangyuan Zhang   +9 more
doaj   +2 more sources

Identifying a Marine-Derived Small-Molecule Nucleoprotein Inhibitor Against Influenza A Virus [PDF]

Marine Drugs
Influenza A virus (IAV) poses a major threat to global public health, exerting immense pressure on human health and the economy. The IAV nucleoprotein (NP) is an ideal target for antiviral drug development.
Zihan Wang, Yang Zhang, Shangjie Xu, Lishan Sun, Hongwei Zhao, Wei Wang   +5 more
doaj   +2 more sources

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]

, 2013
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo, A Portela, AJ McMichael, Alexandria David, Andrew Pekosz, AS McKee, AT Heiny, B Zhou, CJ Wei, CS Ambrose, D Corti, D Grimm, D Zehn, DM Carragher, DT O’Hagan, E de Wit, F Crawford, F Rahman, GA Poland, GE Price, GT Belz, H Hikono, H Hohn, JB Ulmer, JE McElhaney, Jieru Wang, John W. Kappler, JP Christensen, JW Yewdell, K Thueng-in, L Guo, Laura Noges, LE Brown, LL Shu, M Schotsaert, M Wang, Megan K. L. MacLeod, MK MacLeod, MM Cox, MW LaMere, MW Lamere, N Garcon, Niyun Jin, P Marrack, Philippa Marrack, R Sebastian, RA Medina, SL Giannini, T Lambe, TM Wilkinson, U Kees, Y Furuya   +51 more
core   +10 more sources

Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean–Congo Hemorrhagic Fever Virus Nucleoprotein

Vaccines, 2021
Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus.
Thomas Tipih, Mark Heise, Felicity Jane Burt   +2 more
doaj   +1 more source

A Novel Terrestrial Rabies Virus Lineage Occurring in South America: Origin, Diversification, and Evidence of Contact between Wild and Domestic Cycles

Viruses, 2021
The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores.
Diego A. Caraballo, Cristina Lema, Laura Novaro, Federico Gury-Dohmen, Susana Russo, Fernando J. Beltrán, Gustavo Palacios, Daniel M. Cisterna   +7 more
doaj   +1 more source

Nucleoprotein as a Promising Antigen for Broadly Protective Influenza Vaccines

Vaccines, 2023
Annual vaccination is considered as the main preventive strategy against seasonal influenza. Due to the highly variable nature of major viral antigens, such as hemagglutinin (HA) and neuraminidase (NA), influenza vaccine strains should be regularly ...
Alexandra Rak, Irina Isakova-Sivak, Larisa Rudenko   +2 more
doaj   +1 more source

Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein

EMBO Journal, 2022
Influenza virus infection causes considerable morbidity and mortality, but current therapies have limited efficacy. We hypothesized that investigating the metabolic signaling during infection may help to design innovative antiviral approaches.
A. Guillon, Déborah Bréa-Diakite, A. Cezard, Alan Wacquiez, T. Baranek, J. Bourgeais, F. Picou, V. Vasseur, L. Meyer, C. Chevalier, A. Auvet, J. Carballido, Lydie Nadal Desbarats, F. Dingli, A. Turtoi, Audrey Le Gouellec, F. Fauvelle, Amélie Donchet, T. Crépin, P. Hiemstra, C. Paget, D. Loew, O. Hérault, N. Naffakh, R. Le Goffic, M. Si-Tahar   +25 more
semanticscholar   +1 more source

Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor

Dental Journal, 2023
Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV ...
Viol Dhea Kharisma, Santika Lusia Utami, Wahyu Choirur Rizky, Tim Godefridus Antonius Dings, Md Emdad Ullah, Vikash Jakhmola, Alexander Patera Nugraha   +6 more
doaj   +1 more source

Structural insights on the nucleoprotein C-terminal domain of Měnglà virus

Microbiology Spectrum, 2023
Filoviruses depend on the nucleoprotein (NP) to accomplish multiple functions during the viral life cycle. NP is the most abundantly expressed viral protein in infected cells and the main component of the viral nucleocapsid.
Diego Sebastian Ferrero, Omar Tomás Gilabert, Nuria Verdaguer   +2 more
doaj   +1 more source