Results 101 to 110 of about 15,441 (294)

Longitudinal Surveillance of Influenza A Virus Exposure in Wild Boars (Sus scrofa) in Spain (2015–2023): Serologic and Virologic Evidence of Subtype Infections and H5N1 Spillover Risk

Zoonoses and Public Health, Volume 73, Issue 3, Page 191-204, May 2026.
ABSTRACT Introduction Influenza A viruses (IAVs) are responsible for respiratory infections in a wide range of species, including birds, swine and humans. The role of wild boar (Sus scrofa) in IAV epidemiology remains underexplored. Here, we present a longitudinal serologic and virologic surveillance study of wild boars in Spain from 2015 to 2023 ...
Paloma Encinas, Aitor Nogales, Estela Escribano‐Romero, M. Ángeles Martín del Burgo, Jorge Ramón López‐Olvera, José Enrique Granados, Gregorio Mentaberre, Adolfo García‐Sastre, Gustavo del Real   +8 more
wiley   +1 more source

HEPATITIS C VIRUS AND HOST CELL NUCLEAR TRANSPORT MACHINERY: A CLANDESTINE AFFAIR

Frontiers in Microbiology, 2015
There is growing evidence that factors encoded by cytoplasmic replicating viruses functionally interact with components of the nucleocytoplasmic transport apparatus.
Barbara eBonamassa, Francesco eCiccarese, Veronica eDi Antonio, Andrea eContarini, Giorgio ePalù, Gualtiero eAlvisi   +5 more
doaj   +1 more source

Fetuin‐b Mediates Lipid Overload‐Induced Hepatic Lipid Accumulation in Large Yellow Croaker (Larimichthys crocea)

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic of the mechanism of fetuin‐b mediated high‐fat diet‐induced hepatic steatosis in Larimichthys crocea. Lipid overload triggers C/EBPα‐mediated fetuin‐b upregulation. Fetuin‐b drives hepatic lipid accumulation by reprogramming lipid metabolism and inhibiting Plin2 ubiquitination to stabilize lipid droplets, identifying it as a potential ...
Yanan Shen, Qiuchi Chen, Zengqi Zhao, Qiang Chen, Yuhang Tang, Fan Chen, Tingting Hao, Jianlong Du, Qinghui Ai   +8 more
wiley   +1 more source

Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein [PDF]

, 2016
Background: Tospovirus is a plant-infecting genus within the family Bunyaviridae, which also includes four animalinfecting genera: Hantavirus, Nairovirus, Phlebovirus and Orthobunyavirus.
Barbosa, João Alexandre Ribeiro Gonçalves, Faheem, Muhammad, Lima, Rayane Nunes, Melo, Fernando Lucas, Polêto, Marcelo Depólo, Resende, Renato Oliveira, Verli, Hugo   +6 more
core   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, Volume 600, Issue 7, Page 1028-1042, April 2026.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, Volume 20, Issue 4, Page 1022-1040, April 2026.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Extracorporeal treatment of nucleoprotein disposal disorders using the systemic lupus erythematosus model: evaluation of efficacy and safety in a short-term simulated experiment [PDF]

, 2015
А. С. Трофименко, I. P. Gontar, О.В. Парамонова, Е. С. Симакова, I.А. Zborovskaya   +4 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, Volume 20, Issue 4, Page 962-980, April 2026.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, Volume 16, Issue 4, Page 737-750, April 2026.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source