Results 1 to 10 of about 283,393 (336)

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

eLife, 2014
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules.
Zachary Lee Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, Seok-Yong Lee   +6 more
doaj   +3 more sources

Efficient Antibacterial/Antifungal Activities: Synthesis, Molecular Docking, Molecular Dynamics, Pharmacokinetic, and Binding Free Energy of Galactopyranoside Derivatives

Molecules, 2022
The chemistry and biochemistry of carbohydrate esters are essential parts of biochemical and medicinal research. A group of methyl β-d-galactopyranoside (β-MGP, 1) derivatives was acylated with 3-bromobenzoyl chloride and 4-bromobenzoyl chloride in ...
Faez Ahmmed, Anis Ul Islam, Yousef E. Mukhrish, Youness El Bakri, Sajjad Ahmad, Yasuhiro Ozeki, Sarkar M. A. Kawsar   +6 more
doaj   +1 more source

Determination of Amino Acids and Nucleosides in Medicinal and Edible Hybrid Gastrodia elata and Its Parent Varieties Based on Liquid Chromatography-Tandem Mass Spectrometry

Shipin gongye ke-ji, 2023
To provide a scientific basis for the follow-up resource utilization and food development of Jinzhai hybrid G. elata, the ultra-high performance liquid chromatography coupled with mass spectrometry was utilized to accurately determine the contents of ...
Guangzheng WANG, Qingqing GONG, Nianjun YU, Hanbo GAO, Lihua XING, Fangping DU   +5 more
doaj   +1 more source

Nucleoside Sensing [PDF]

Sensors, 2006
A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael, Klärner, Frank-Gerrit, Schrader, Thomas   +2 more
openaire   +2 more sources

Radiosensitizing Nucleosides [PDF]

JNCI Journal of the National Cancer Institute, 1996
Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers.
C J, McGinn, D S, Shewach, T S, Lawrence
openaire   +2 more sources

In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Synthesis of Novel N⁴-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents

Pharmaceuticals, 2022
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi   +11 more
doaj   +1 more source

18Oxygen Substituted Nucleosides Combined with Proton Beam Therapy: Therapeutic Transmutation In Vitro [PDF]

International Journal of Particle Therapy, 2021
Purpose: Proton therapy precisely delivers radiation to cancers to cause damaging strand breaks to cellular DNA, kill malignant cells, and stop tumor growth.
Tyvin Rich, MD, Dongfeng Pan, PhD, Mahendra Chordia, PhD, Cynthia Keppel, PhD, David Beylin, MS, Pavel Stepanov, MS, Mira Jung, PhD, Dalong Pang, PhD, Scott Grindrod, PhD, Anatoly Dritschilo, MD   +9 more
doaj   +1 more source

1H-NMR SPECTROSCOPY TO MEASURE THE KI INDEX OF BOMBAY DUCKS DURING CHILLING STORAGE AS AN APPROACH TO DETERMINE FRESHNESS

Squalen, 2023
The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah, Tati Nurhayati, Hedi Indra Januar, Agoes Mardiono Jacoeb   +3 more
doaj   +1 more source

Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides

Molecules, 2022
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not easily
Diego E. Escalante, Courtney C. Aldrich, David M. Ferguson   +2 more
doaj   +1 more source