Results 1 to 10 of about 142,129 (312)
Molecules, 2022 The chemistry and biochemistry of carbohydrate esters are essential parts of biochemical and medicinal research. A group of methyl β-d-galactopyranoside (β-MGP, 1) derivatives was acylated with 3-bromobenzoyl chloride and 4-bromobenzoyl chloride in ...
Faez Ahmmed +6 more
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Shipin gongye ke-ji, 2023 To provide a scientific basis for the follow-up resource utilization and food development of Jinzhai hybrid G. elata, the ultra-high performance liquid chromatography coupled with mass spectrometry was utilized to accurately determine the contents of ...
Guangzheng WANG +5 more
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Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
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Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T. +9 more
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Sensors, 2006 A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael +2 more
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Thermodynamic reaction control of nucleoside phosphorolysis [PDF]
, 2020 Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments. Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are widely employed for the synthesis of pentose‐1‐phosphates and nucleoside ...
Giessmann, Robert T. +4 more
core +1 more source
Squalen, 2023 The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah +3 more
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Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents
Pharmaceuticals, 2022 Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard +11 more
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Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]
, 2002 This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Bickel, M +11 more
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