Results 1 to 10 of about 146,613 (150)

Efficient Antibacterial/Antifungal Activities: Synthesis, Molecular Docking, Molecular Dynamics, Pharmacokinetic, and Binding Free Energy of Galactopyranoside Derivatives

Molecules, 2022
The chemistry and biochemistry of carbohydrate esters are essential parts of biochemical and medicinal research. A group of methyl β-d-galactopyranoside (β-MGP, 1) derivatives was acylated with 3-bromobenzoyl chloride and 4-bromobenzoyl chloride in ...
Faez Ahmmed, Anis Ul Islam, Yousef E. Mukhrish, Youness El Bakri, Sajjad Ahmad, Yasuhiro Ozeki, Sarkar M. A. Kawsar   +6 more
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Determination of Amino Acids and Nucleosides in Medicinal and Edible Hybrid Gastrodia elata and Its Parent Varieties Based on Liquid Chromatography-Tandem Mass Spectrometry

Shipin gongye ke-ji, 2023
To provide a scientific basis for the follow-up resource utilization and food development of Jinzhai hybrid G. elata, the ultra-high performance liquid chromatography coupled with mass spectrometry was utilized to accurately determine the contents of ...
Guangzheng WANG, Qingqing GONG, Nianjun YU, Hanbo GAO, Lihua XING, Fangping DU   +5 more
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1H-NMR SPECTROSCOPY TO MEASURE THE KI INDEX OF BOMBAY DUCKS DURING CHILLING STORAGE AS AN APPROACH TO DETERMINE FRESHNESS

Squalen, 2023
The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah, Tati Nurhayati, Hedi Indra Januar, Agoes Mardiono Jacoeb   +3 more
doaj   +1 more source

Synthesis of Novel N⁴-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents

Pharmaceuticals, 2022
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi   +11 more
doaj   +1 more source

Glycosyl-Nucleolipids as New Bioinspired Amphiphiles

Molecules, 2013
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential
Philippe Barthélémy, Eric Amigues, Amit Patwa, Laurent Latxague   +3 more
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Oxalyl retro-peptide gelators. Synthesis, gelation properties and stereochemical effects

Beilstein Journal of Organic Chemistry, 2010
In this work we report on gelation properties, self-assembly motifs, chirality effects and morphological characteristics of gels formed by chiral retro-dipeptidic gelators in the form of terminal diacids (1a–5a) and their dimethyl ester (1b–5b) and ...
Janja Makarević, Milan Jokić, Leo Frkanec, Vesna Čaplar, Nataša Šijaković Vujičić, Mladen Žinić   +5 more
doaj   +1 more source

Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years

Molecules, 2017
Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis ...
Hanadi Sinokrot, Tasneem Smerat, Anas Najjar, Rafik Karaman   +3 more
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In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Effect of Endurance Training and Adenosine Injection on CCL2 Expression in Brain Ischemia-Reperfusion in Male Rats

مجله علمی دانشگاه علوم پزشکی کردستان, 2021
Background and Aim: Regular exercise and proper exercise programs contribute to improvement of physiological function and improve aerobic capacity, blood absorption, and adequate oxygen supply for the brain and muscles.
mohammad dehafarin, farah nameni
doaj  

Adenosine as a signaling molecule in the retina: biochemical and developmental aspects

Anais da Academia Brasileira de Ciências, 2002
The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj   +1 more source