Results 1 to 10 of about 339,632 (390)

Efficient Antibacterial/Antifungal Activities: Synthesis, Molecular Docking, Molecular Dynamics, Pharmacokinetic, and Binding Free Energy of Galactopyranoside Derivatives

Molecules, 2022
The chemistry and biochemistry of carbohydrate esters are essential parts of biochemical and medicinal research. A group of methyl β-d-galactopyranoside (β-MGP, 1) derivatives was acylated with 3-bromobenzoyl chloride and 4-bromobenzoyl chloride in ...
Faez Ahmmed, Anis Ul Islam, Yousef E. Mukhrish, Youness El Bakri, Sajjad Ahmad, Yasuhiro Ozeki, Sarkar M. A. Kawsar   +6 more
doaj   +1 more source

Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viruses, 2021
The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of ...
R. Geraghty, M. Aliota, L. Bonnac
semanticscholar   +1 more source

Determination of Amino Acids and Nucleosides in Medicinal and Edible Hybrid Gastrodia elata and Its Parent Varieties Based on Liquid Chromatography-Tandem Mass Spectrometry

Shipin gongye ke-ji, 2023
To provide a scientific basis for the follow-up resource utilization and food development of Jinzhai hybrid G. elata, the ultra-high performance liquid chromatography coupled with mass spectrometry was utilized to accurately determine the contents of ...
Guangzheng WANG, Qingqing GONG, Nianjun YU, Hanbo GAO, Lihua XING, Fangping DU   +5 more
doaj   +1 more source

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]

, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T., Kaspar, Felix, Klare, Hendrik F. T., Kurreck, Jens, Neubauer, Peter, Paulick, Katharina, Röhrs, Viola, Wagner, Anke, Westarp, Sarah, Yehia, Heba   +9 more
core   +1 more source

Antiviral nucleoside analogs

Chemistry of Heterocyclic Compounds, 2021
The minireview surveys the modification of native nucleosides as a result of which huge libraries of nucleoside analogs of various structures were synthesized.
V. Kataev, B. Garifullin
semanticscholar   +1 more source

Synthesis of Novel N⁴-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents

Pharmaceuticals, 2022
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi   +11 more
doaj   +1 more source

18Oxygen Substituted Nucleosides Combined with Proton Beam Therapy: Therapeutic Transmutation In Vitro [PDF]

International Journal of Particle Therapy, 2021
Purpose: Proton therapy precisely delivers radiation to cancers to cause damaging strand breaks to cellular DNA, kill malignant cells, and stop tumor growth.
Tyvin Rich, MD, Dongfeng Pan, PhD, Mahendra Chordia, PhD, Cynthia Keppel, PhD, David Beylin, MS, Pavel Stepanov, MS, Mira Jung, PhD, Dalong Pang, PhD, Scott Grindrod, PhD, Anatoly Dritschilo, MD   +9 more
doaj   +1 more source

1H-NMR SPECTROSCOPY TO MEASURE THE KI INDEX OF BOMBAY DUCKS DURING CHILLING STORAGE AS AN APPROACH TO DETERMINE FRESHNESS

Squalen, 2023
The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah, Tati Nurhayati, Hedi Indra Januar, Agoes Mardiono Jacoeb   +3 more
doaj   +1 more source

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

ACS Medicinal Chemistry Letters, 2020
While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant ...
Victoria C. Yan, F. Muller
semanticscholar   +1 more source

Purine nucleoside phosphorylase deficiency

Atlas of Inherited Metabolic Diseases, 2020
People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar   +1 more source