Results 101 to 110 of about 339,632 (390)

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

An Expeditious Total Synthesis of 5′-Deoxy-toyocamycin and 5′-Deoxysangivamycin

Molecules, 2019
In present paper, an expeditious total synthesis of naturally occurring 5′-deoxytoyocamycin and 5′-deoxysangivamycin was accomplished. Because of the introduction of a benzoyl group at N-6 of 4-amino-5-cyano-6-bromo-pyrrolo[2,3-d]pyrimidine ...
Xiangyou Dong, Jie Tang, Chen Hu, Jiang Bai, Haixin Ding, Qiang Xiao   +5 more
doaj   +1 more source

Effect of genotype on duodenal expression of nutrient transporter genes in dairy cows [PDF]

, 2013
peer-reviewedBackground Studies have shown clear differences between dairy breeds in their feed intake and production efficiencies. The duodenum is critical in the coordination of digestion and absorption of nutrients.
Buckley, Frank, Kenny, David A., Keogh, Kate, Waters, Sinead M.   +3 more
core   +1 more source

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Nature, 2014
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case fatality rates of filovirus disease outbreaks are among the highest reported for any human pathogen, exceeding 90% (ref. 1).
Travis K Warren, Jay B. Wells, R. Panchal, Kelly S. Stuthman, N. Garza, Sean A. van Tongeren, Lián Dǒng, Cary J. Retterer, Brett Eaton, Gianluca Pegoraro, S. Honnold, S. Bantia, P. Kotian, Xilin Chen, Brian R. Taubenheim, Lisa S. Welch, Dena M. Minning, Y. Babu, W. Sheridan, S. Bavari   +19 more
semanticscholar   +1 more source

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source

Enhancing the Yield of Pleurotus ostreatus Through the Addition of Nucleotides and Nucleosides

Journal of Fungi
Pleurotus ostreatus is a mushroom species renowned for its abundant nutritional and medicinal properties. Nevertheless, the yield of its fruiting bodies has long remained at a standstill, making it arduous to achieve substantial improvements. Because the
Chenmin Tang, Yixuan Gao, Zhiguo An, Abdul Qadeer Sajid, Hanjie Ying, Zhenyu Wang, Dong Liu   +6 more
doaj   +1 more source

Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5 Position

Chemosensors, 2015
Nucleic acids that change their properties upon photo-irradiation could be powerful materials for molecular sensing with high spatiotemporal resolution.
Shohei Mori, Kunihiko Morihiro, Yuuya Kasahara, Shin-ichi Tsunoda, Satoshi Obika   +4 more
doaj   +1 more source

Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2

Nature, 2022
D. Schultz, Robert M. Johnson, K. Ayyanathan, Jesse Miller, Kanupriya Whig, Brinda Kamalia, M. Dittmar, S. Weston, Holly Hammond, C. Dillen, J. Ardanuy, L. Taylor, Jae Seung Lee, Minghua Li, Emily M. Lee, Clarissa Shoffler, Christopher Petucci, S. Constant, M. Ferrer, Christoph A. Thaiss, M. Frieman, Sara Cherry   +21 more
semanticscholar   +1 more source

Identification of tRNA nucleoside modification genes critical for stress response and development in rice and Arabidopsis

BMC Plant Biology, 2017
Modification of nucleosides on transfer RNA (tRNA) is important either for correct mRNA decoding process or for tRNA structural stabilization. Nucleoside methylations catalyzed by MTase (methyltransferase) are the most common type among all tRNA ...
Youmei Wang, Chaoqun Pang, Xukai Li, Zhen Hu, Zhengyi Lv, B. Zheng, Peng Chen   +6 more
semanticscholar   +1 more source

Nucleoside Transporter Proteins

Current Vascular Pharmacology, 2009
Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of nucleoside-derived drugs, mostly used in anticancer therapy. SLC28 and SLC29 families consist in three and four members, respectively, which differ in their substrate selectivity and their ...
F. Javier Casado, Miriam Molina-Arcas, Marçal Pastor-Anglada   +2 more
openaire   +4 more sources