Results 101 to 110 of about 146,762 (298)

Exploring the Discrepancies in the Biological Activities of Extracts From Guadua angustifolia Var. Bicolor Londoño Collected in Two Different Sites

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Guadua angustifolia var. bicolor Lodoño is a Colombian bamboo species that has shown promising medicinal properties. This study aims to investigate the differences in the chemical composition and biological activity of extracts from two different populations of G. angustifolia var. bicolor, collected in Bauru and Tatuí, Brazil.
João Kazlauckas   +2 more
wiley   +1 more source

Characterization of DnaB–DnaG Interaction in M. tuberculosis Using Small‐Angle X‐ray Scattering‐Based Dissociation Assay

open access: yesChemBioChem, EarlyView.
The study characterizes interactions between DnaB helicase and DnaG primase in Mycobacterium tuberculosis using small‐angle X‐ray scattering, surface plasmon resonance, and cross‐linking. The findings reveal that DnaG forms dimers in solution, which are destabilized upon DnaB binding.
Dayan A, Ilic S, Akabayov B
wiley   +1 more source

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes

open access: yesChemBioChem, EarlyView.
Group II Introns (G2Is) are large self‐splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2, an unexpectedly proficient ribozyme, self‐splices not only in vitro, but also in Escherichia coli cells.
Deni Szokoli   +3 more
wiley   +1 more source

1H-1,2,3-triazolyl-1,6-naphthyridin-7(6H)-ones as Potential Fluorescent Nucleoside Analogues: Synthesis and Optical Properties

open access: yesMolecules
In this article, we present the synthesis and the optical properties of three original molecules as potential fluorescent ribonucleoside analogues incorporating a 1,6-naphthyridin-7(6H)-one scaffold as a fluorescent nucleobase and a 1,2,3-triazole as a ...
Anissa Beghennou   +3 more
doaj   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

open access: yesChemBioChem, EarlyView.
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Nathalie J. Kurrle   +8 more
wiley   +1 more source

Chemical reactivity, molecular electrostatic potential, FTIR, NMR, in vitro, and in silico studies of mannopyranoside derivatives: 3-Nitrobenzoylation leads to improve antimicrobial activity

open access: yesChemical Physics Impact
This investigation Extensively explored the synthesis and potential therapeutic applications of derivatives derived from methyl α-d-mannopyranoside.
Shahin Sultana   +5 more
doaj  

The Interactions of Anti-HIV Pronucleotides with a Model Phospholipid Membrane

open access: yesMolecules
Pronucleotides, after entering the cell, undergo chemical or enzymatic conversion into nucleotides with a free phosphate residue, and the released nucleoside 5′-monophosphate is then phosphorylated to the biologically active form, namely nucleoside 5 ...
Monika Rojewska   +4 more
doaj   +1 more source

Sustainable Approaches for the Protection and Deprotection of Functional Groups

open access: yesChemistry – A European Journal, EarlyView.
Shield: Protection and deprotection are key to selective synthesis, but conventional methods can lack sustainability. This review highlights electrochemical and photochemical strategies as greener alternatives, emphasizing their mechanisms, functional group tolerance, and broad synthetic utility.
Ju Ha Jin   +5 more
wiley   +1 more source

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