Results 141 to 150 of about 171,665 (294)

Direct and efficient synthesis of nucleosides through the ortho-(tert-butylethynyl)phenyl thioglycosides (BEPTs) protocol. [PDF]

Nat Commun
Liu H, Wang MY, Xie H, Qiu Y, Mao T, Shen X, Liu XX, Guo JJ, Tang MZ, Liao JX, Tu YH, Liu DY, Sun JS.   +12 more
europepmc   +1 more source

Biologically Active Nucleosides [PDF]

Current Protocols in Nucleic Acid Chemistry, 2005
openaire   +11 more sources

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease. [PDF]

Pharmacol Res Perspect
Wu KC, Lin CY, Tran T, Lin JH, Yeh HH, Ho CJ, Chern Y, Lin CJ.   +7 more
europepmc   +1 more source

Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches

ChemSusChem, EarlyView.
Developing a process to produce glycosylated natural products involves many decisions, and given the current climate crisis, the environmental impact of the various processes must be a major consideration. This review provides an overview of the various processes and a framework for which metrics should be quantified to select processes that are both ...
Felipe Mejia‐Otalvaro, Brianna Marie Lax, Onur Kırtel, Ditte Hededam Welner   +3 more
wiley   +1 more source

Epigenetic Drivers of Chemoresistance in Nucleobase and Nucleoside Analog Therapies. [PDF]

Biology (Basel)
Kaszycki J, Kim M.
europepmc   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

Biochemical Studies of the Nucleoside Analogue, Formycin

, 1969
David C. Ward, Anthony Cerami, E. Reich, George Acs, Lynne Altwerger   +4 more
openalex   +1 more source

Spiro[3.3]heptane: A Versatile sp3‐Rich Scaffold and its Synthetic Routes

European Journal of Organic Chemistry, EarlyView.
The sp3‐rich spiro[3.3]heptane scaffold is a saturated, 3D bioisostere of benzene. This review summarizes key synthetic strategies, including [2+2] cyclizations and bond disconnections at C1C2 or C4 (spiro‐carbon) positions, offering a practical guide for accessing this emerging motif and expanding drug‐like chemical space.
Myunggi Jung
wiley   +1 more source

Characteristics of the Utilization of Nucleosides by Embryos of Paracentrotus lividus

, 1962
Martin Nemer
openalex   +1 more source