Results 171 to 180 of about 235,474 (365)

Inhibition of Surfactin Biosynthesis in Bacillus Subtilis Using Cell‐Permeable Adenylation Domain Inhibitors

ChemBioChem, EarlyView.
L‐Leu‐AMS‐based adenylation domain inhibitors with the modification of 2′‐OH in the adenosine skeleton are synthesized. Coupled with affinity‐based protein profiling of nonribosomal peptide synthetases (NRPSs), their activities toward surfactin‐NRPSs in Bacillus subtilis are evaluated.
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe   +3 more
wiley   +1 more source

NF-KB protein purification from bovine spleen: Nucleotide stimulation and binding site specificity [PDF]

, 1988
The activity of the enhancer for the κ immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-κB protein. We purified NF-κB over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and ...
Baltimore, David, Gifford, Ann, Kuang, Anna, Lenardo, Michael J.   +3 more
core  

Effect of Nucleosides on Acute Left Ventricular Failure in the Isolated Dog Heart [PDF]

, 1959
N. M. Buckley, K.K. Tsuboi, Norman J. Zeig   +2 more
openalex   +1 more source

Lumos: A β‐Diketone‐Derived Artificial Nucleobase Forming Inter‐Strand Complexes in DNA that Promote Lanthanoid Ion Luminescence

ChemistryEurope, EarlyView.
A novel artificial nucleobase, 1‐(3‐(hydroxymethyl)phenyl)‐3‐phenylpropane‐1,3‐dione (HdbmOR), bearing a β‐diketone functionality and designed to form inter‐strand complexes that resemble lanthanoid‐mediated base pairs, was developed. The antenna effect of HdbmOR promoting luminescence of EuIII and SmIII is retained upon incorporation into short ...
Carla Bardehle, Marian Hebenbrock, Alexander Hepp, Jens Müller   +3 more
wiley   +1 more source

Unexpected Accumulation of ncm\u3csup\u3e5\u3c/sup\u3eU and ncm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU in a \u3cem\u3etrm9\u3c/em\u3e Mutant Suggests an Additional Step in the Synthesis of mcm\u3csup\u3e5\u3c/sup\u3eU and mcm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU [PDF]

, 2011
Background Transfer RNAs are synthesized as a primary transcript that is processed to produce a mature tRNA. As part of the maturation process, a subset of the nucleosides are modified.
Anderson, James T., Byström, Anders S., Chen, Changchun, Huang, Bo   +3 more
core   +1 more source

Phosphorylmuramic Acid in Lactobacillus casei. Its Presence in Protein and in a Nucleoside-pyrophosphate Fraction. [PDF]

, 1959
Carl‐Henric de Verdier, Gunnar Ågren, E. Hammarsten, C.‐G. Hedén, B. Malmgren, H. Palmstierna   +5 more
openalex   +1 more source

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

1H-1,2,3-triazolyl-1,6-naphthyridin-7(6H)-ones as Potential Fluorescent Nucleoside Analogues: Synthesis and Optical Properties

Molecules
In this article, we present the synthesis and the optical properties of three original molecules as potential fluorescent ribonucleoside analogues incorporating a 1,6-naphthyridin-7(6H)-one scaffold as a fluorescent nucleobase and a 1,2,3-triazole as a ...
Anissa Beghennou, Océane Rondot, Vincent Corcé, Candice Botuha   +3 more
doaj   +1 more source

A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N1‐Methyladenosine in Urine Samples

Chemistry – A European Journal, EarlyView.
Using N1‐methyladenosine, a cancer biomarker as a target, a highly selective DNA aptamer was obtained with excellent selectivity and affinity, allowing the detection with a limit of detection of 1.9 µm. Abstract N1‐methyladenosine (m1A) level in urine increases in the presence of cancer and is associated with the tumor size and stage.
Esra Bağda, Efkan Bağda, Juewen Liu
wiley   +1 more source

Water‐Soluble Pd‐Imidate Complexes as Versatile Catalysts for the Modification of Unprotected Halonucleosides

The Chemical Record, Volume 22, Issue 12, December 2022., 2022
Three generations of neutral and anionic water‐soluble palladium complexes act as versatile catalysts for the modification of unprotected halonucleosides. Abstract Modification of unprotected nucleosides has been attracting continuous interest, since these building blocks themselves and their phosphate‐upgraded corresponding nucleotides have shown a ...
José Luis Serrano
wiley   +1 more source