Results 41 to 50 of about 283,393 (336)

Enhancing the Yield of Pleurotus ostreatus Through the Addition of Nucleotides and Nucleosides

Journal of Fungi
Pleurotus ostreatus is a mushroom species renowned for its abundant nutritional and medicinal properties. Nevertheless, the yield of its fruiting bodies has long remained at a standstill, making it arduous to achieve substantial improvements. Because the
Chenmin Tang, Yixuan Gao, Zhiguo An, Abdul Qadeer Sajid, Hanjie Ying, Zhenyu Wang, Dong Liu   +6 more
doaj   +1 more source

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

Molecules, 2019
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance.
Mary K. Yates, Payel Chatterjee, Mike Flint, Yafet Arefeayne, Damjan Makuc, Janez Plavec, Christina F. Spiropoulou, Katherine L. Seley-Radtke   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]

, 2020
International ...
Boissan, Mathieu, Farkas, Zsolt, Kopper, László, Mehta, Anil, Mátyási, Barbara, Sebestyén, Anna, Takács-Vellai, Krisztina   +6 more
core   +4 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro. [PDF]

, 2018
On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons ...
Barnard, Dale L, Beadle, James R, Hostetler, Karl Y, Kumaki, Yohichi, Mclean, Tyler Z, Roth, Jason P, Smee, Donald F, Valiaeva, Nadejda, Woolcott, John D   +8 more
core  

The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters [PDF]

, 2014
The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner
Agrimi, G., Cirigliano, A., Di Noia, M. A., Iacobazzi, V., Palmieri, Ferdinando, Rinaldi, T., Todisco, S.   +6 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

Pediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao, Tzee-Chung Wu, Ching-Feng Huang, Chih-Chung Lin, I-Fei Huang, Lite Wu   +5 more
doaj   +1 more source

General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]

, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S., Diener, Dennis R., Gopal, Radhika, Ishikawa, Takashi, King, Stephen M., Liu, Yi, Maizy, Yousif, Poghosyan, Emiliya, Yang, Pinfen, Zhu, Xiaoyan   +9 more
core   +1 more source