Results 51 to 60 of about 340,942 (336)

Chemical reactivity, molecular electrostatic potential, FTIR, NMR, in vitro, and in silico studies of mannopyranoside derivatives: 3-Nitrobenzoylation leads to improve antimicrobial activity

Chemical Physics Impact
This investigation Extensively explored the synthesis and potential therapeutic applications of derivatives derived from methyl α-d-mannopyranoside.
Shahin Sultana, Md. Ahad Hossain, Suvro Biswas, Md. Abu Saleh, Ferdausi Ali, Sarkar M.A. Kawsar   +5 more
doaj   +1 more source

Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro [PDF]

, 2016
A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay.
Li, Depeng, Ma, Kedong, Qin, Jianzhong, Xu, Yaozhong, Zhang, Xiaohui   +4 more
core   +1 more source

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

Antiviral Research, 2018
This is the second of two invited articles reviewing the development of nucleoside analogue antiviral drugs, written for a target audience of virologists and other non-chemists, as well as chemists who may not be familiar with the field.
Mary K Yates, K. Seley‐Radtke
semanticscholar   +1 more source

The Interactions of Anti-HIV Pronucleotides with a Model Phospholipid Membrane

Molecules
Pronucleotides, after entering the cell, undergo chemical or enzymatic conversion into nucleotides with a free phosphate residue, and the released nucleoside 5′-monophosphate is then phosphorylated to the biologically active form, namely nucleoside 5 ...
Monika Rojewska, Joanna Romanowska, Adam Kraszewski, Michał Sobkowski, Krystyna Prochaska   +4 more
doaj   +1 more source

Emerging Roles of Nucleoside Transporters

Frontiers in Pharmacology, 2018
Since human Nucleoside Transporters (hNTs) were identified by their activity as transport systems, extensive work has been done to fully characterize them at the molecular and physiological level. Many efforts have been addressed to the identification of
M. Pastor-Anglada, S. Pérez-Torras
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Enhancing the Yield of Pleurotus ostreatus Through the Addition of Nucleotides and Nucleosides

Journal of Fungi
Pleurotus ostreatus is a mushroom species renowned for its abundant nutritional and medicinal properties. Nevertheless, the yield of its fruiting bodies has long remained at a standstill, making it arduous to achieve substantial improvements. Because the
Chenmin Tang, Yixuan Gao, Zhiguo An, Abdul Qadeer Sajid, Hanjie Ying, Zhenyu Wang, Dong Liu   +6 more
doaj   +1 more source

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

Molecules, 2019
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance.
Mary K. Yates, Payel Chatterjee, Mike Flint, Yafet Arefeayne, Damjan Makuc, Janez Plavec, Christina F. Spiropoulou, Katherine L. Seley-Radtke   +7 more
doaj   +1 more source

Selective Formation of Intramolecular Hydrogen-Bonding Palladium(II) Complexes with Nucleosides Using Unsymmetrical Tridentate Ligands

Molecules, 2022
Three palladium(II) complexes with amino-amidato-phenolato-type tridentate ligands were synthesized and characterized by 1H NMR spectroscopy and X-ray crystallography.
Ryoji Mitsuhashi, Yuya Imai, Takayoshi Suzuki, Yoshihito Hayashi   +3 more
doaj   +1 more source

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

Antiviral Chemistry & Chemotherapy, 2018
Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses.
L. Eyer, Radim Nencka, E. De Clercq, K. Seley‐Radtke, D. Růžek   +4 more
semanticscholar   +1 more source