18Oxygen Substituted Nucleosides Combined with Proton Beam Therapy: Therapeutic Transmutation In Vitro [PDF]
International Journal of Particle Therapy, 2021 Purpose: Proton therapy precisely delivers radiation to cancers to cause damaging strand breaks to cellular DNA, kill malignant cells, and stop tumor growth.
Tyvin Rich, MD +9 more
doaj +1 more source
Adding alchemical variables to metadynamics to enhance sampling in free energy calculations [PDF]
, 2022 Performing alchemical transformations, in which one molecular system is nonphysically changed to another system, is a popular approach adopted in performing free energy calculations associated with various biophysical processes, such as protein-ligand binding or the transfer of a molecule between environments.
arxiv +1 more source
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake [PDF]
, 2013 It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol.
Al-Salabi +47 more
core +1 more source
Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]
, 2010 <b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
De Koning, H.P. +2 more
core +4 more sources
Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells**
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Protein post‐translational modifications allow cells to swiftly adjust activity and localization of proteins. Here, we developed a chemical proteomic approach to determine a protein tyrosination status using an O‐propargyl tyrosine probe. We show that tyrosination modifies previously described alpha‐tubulins with ‐EEY C‐terminal sequence together with ...
Dmytro Makarov, Pavel Kielkowski
wiley +1 more source
Mechanochemistry of nucleosides, nucleotides and related materials
Beilstein Journal of Organic Chemistry, 2018 The application of mechanical force to induce the formation and cleavage of covalent bonds is a rapidly developing field within organic chemistry which has particular value in reducing or eliminating solvent usage, enhancing reaction rates and also in ...
Olga Eguaogie +4 more
doaj +1 more source
A nucleobase-centered coarse-grained representation for structure prediction of RNA motifs [PDF]
Nucleic Acids Res. 46, 1674 (2018), 2017 We introduce the SPlit-and-conQueR (SPQR) model, a coarse-grained representation of RNA designed for structure prediction and refinement. In our approach, the representation of a nucleotide consists of a point particle for the phosphate group and an anisotropic particle for the nucleoside.
arxiv +1 more source
Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
core +1 more source
Broadband terahertz time-domain spectroscopy and fast FMCW imaging: principle and applications [PDF]
, 2020 We report a broadband terahertz time-domain spectroscopy (THz-TDS) which enables twenty vibrational modes of adenosine nucleoside to be resolved in a wide frequency range of 1-20 THz. The observed spectroscopic features of adenosine are in good agreement with the published spectra obtained using Fourier Transform Infrared Spectroscopy (FTIR) and Raman ...
arxiv +1 more source
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières [PDF]
, 2008 OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival.
Alexandra Calmy +24 more
core +2 more sources