Results 71 to 80 of about 146,762 (298)

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

BIẾN ĐỔI VÒNG ĐƯỜNG XYLOSE THÀNH CÁC CHẤT TRUNG GIAN CHO QUÁ TRÌNH TỔNG HỢP THUỐC TRỊ UNG THƯ, KHÁNG VIRUT HIV

Tạp chí Khoa học Đại học Cần Thơ, 2008
Xylose được biết đến như một trong những nguyên liệu đầu của việc tổng hợp thuốc trị bệnh ung thư, AIDS và một số bệnh khác.  Việc tổng hợp những dẫn xuất trung gian quan trọng để điều chế những thuốc này đã đạt được.
Trương Thị Minh Hải, Lê Thanh Phước   +1 more
doaj  

Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

Animal Models and Experimental Medicine, EarlyView.
This represents the first serial hepatocyte transplantation pig model designed to investigate the massive hepatocyte proliferation in vivo. Leveraging this novel model, we achieved serial hepatocyte transplantation and regeneration in a porcine model, where the transplanted hepatocytes effectively repopulated the livers of two‐generation model pigs in ...
Zhiqiang Han, Xin Wang, Dawei Yu, Jing Wang, Ke Sun, Siqi Wang, Ying Zhang, Guihai Feng, Wei Li, Tang Hai, Jilong Ren   +10 more
wiley   +1 more source

FTIR, 1H-/13C-NMR spectral characterization, antimicrobial, anticancer, antioxidant, anti-inflammatory, PASS, SAR, and in silico properties of methyl α-D-glucopyranoside derivatives

Chemical Physics Impact
A novel series of biologically active derivatives based on methyl α-D-glucopyranoside (MGP) has been developed, comprising 6-O-monosubstituted MGP derivatives obtained from methyl α-D-glucopyranoside.
Jannatul Ferdous, Faizan Abul Qais, Ferdausi Ali, Debashis Palit, Imtiaj Hasan, Sarkar M.A. Kawsar   +5 more
doaj  

Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)

Journal of Biological Chemistry, 1964
Abstract Previous physical studies from this laboratory by sedimentation velocity and diffusion and by sedimentation equilibrium (Yue, R. H., Ratliff, R. L., and Kuby, S. A. (1967) Biochemistry 6, 2923–2932) have permitted an assignment of the kinetic molecular weight of the crystalline brewers' yeast nucleoside diphosphokinase, namely 102,000 (±2,000)
Lily Wu, Richard H. Palmieri, Hans K. Jacobs, Lynn Maland, Stephen A. Kuby, Robert H. Yue   +5 more
openaire   +2 more sources

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Determination and comparative analysis of 13 nucleosides and nucleobases in natural fruiting body of Ophiocordyceps sinensis and its substitutes

Mycology, 2017
Nucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches
Wenming Cheng, Xun Zhang, Qiang Song, Weili Lu, Tingni Wu, Qunlin Zhang, Chunru Li   +6 more
doaj   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

The Uses of 2-Ethoxy-(4H)-3,1-benzoxazin-4-one in the Synthesis of Some Quinazolinone Derivatives of Antimicrobial Activity

Pharmaceuticals, 2011
The behavior of 2-ethoxy-(4H)-3,1-benzoxazin-4-one (1) towards nitrogen nucleo-philes, e.g. ethanolamine, aromatic amines (namely: p-toluidine, p-anisidine, p-hydroxyaniline, o-hydroxyaniline, o-bromoaniline, o-phenylenediamine, p-phenylene- diamine, o ...
Fakhry A. El-Bassiouny, Sameh A. Rizk, Khalid M. Darwish, Maher A. El-Hashash   +3 more
doaj   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, EarlyView.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source