Results 61 to 70 of about 42,345 (197)

A sequential direct arylation/Suzuki-Miyaura cross-coupling transformation of unprotected 2 '-deoxyadenosine affords a novel class of fluorescent analogues [PDF]

, 2010
Novel rigid 8-biaryl-2'-deoxyadenosines with tuneable fluorescent properties can be accessed by an efficient sequential catalytic Pd-0-coupling ...
Baumann, C.G., Fairlamb, I.J.S., Storr, T.E., Strohmeier, J.A.   +3 more
core   +1 more source

Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues

CHIMIA, 2022
Over the past two and a half years the world has seen a desperate scramble to find a treatment for SARS-CoV-2 and COVID. In that regard, nucleosides have long served as the cornerstone to antiviral treatments due to their resemblance to the naturally ...
Joy E. Thames, Katherine L. Seley-Radtke
doaj   +1 more source

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]

, 1991
The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K, Malik, F, Ohashi, S, Okuno, M, Shimizu, T, Toyoshima, YY, Vale, RD   +6 more
core   +2 more sources

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations

mBio, 2017
The coronavirus (CoV) RNA genome is the largest among the single-stranded positive-sense RNA viruses. CoVs encode a proofreading 3′-to-5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is responsible for CoV high-fidelity replication ...
Kevin W. Graepel, Xiaotao Lu, James Brett Case, Nicole R. Sexton, Everett Clinton Smith, Mark R. Denison   +5 more
doaj   +1 more source

Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus [PDF]

, 2017
Objectives Although monotherapy (mART) effectiveness in maintaining viral suppression and CD4 cell count has been extensively examined in HIV-1-infected patients, its impact on HIV-1 reservoir, immune activation, microbial translocation and co-infection
Carmona, Francesco, Cattelan, Anna Maria, De Rossi, Anita, Del Bianco, Paola, Freguja, Riccardo, Petrara, Maria Raffaella, Sanavia, Silvia, Sasset, Lolita, Zanchetta, Marisa   +8 more
core   +7 more sources

DNA Replication: From Radioisotopes to Click Chemistry

Molecules, 2018
The replication of nuclear and mitochondrial DNA are basic processes assuring the doubling of the genetic information of eukaryotic cells. In research of the basic principles of DNA replication, and also in the studies focused on the cell cycle, an ...
Anna Ligasová, Karel Koberna
doaj   +1 more source

Synthesis and Antiviral Evaluation of 3′-Fluoro-5′-norcarbocyclic Nucleoside Phosphonates Bearing Uracil and Cytosine as Potential Antiviral Agents

Molecules, 2020
Carbocyclic nucleoside analogues are an essential class of antiviral agents and are commonly used in the treatment of viral diseases (hepatitis B, AIDS).
Pierre-Yves Geant, Jean-Pierre Uttaro, Christian Périgaud, Christophe Mathé   +3 more
doaj   +1 more source

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside

Nucleic Acids Research, 1995
Acyclic nucleoside analogues with carboxamido- or nitro-substituted heterocyclic bases have been evaluated for their possible use as universal bases in oligodeoxynucleotides. The acyclic moiety endows the constructs with enough flexibility to allow good base stacking.
Van Aerschot, Arthur, Rozenski, Jef, Loakes, D., Pillet, N., Schepers, G., Herdewijn, Piet   +5 more
openaire   +3 more sources

New trends for metal complexes with anticancer activity [PDF]

, 2008
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is,
Ang, Ang, Barnard, Barnes, Bednarski, Bergamo, Bregman, Calderone, Casini, Debreczeni, Dixon, Dyson, Failes, Feazell, Guo, Habtemariam, Hall, Hambley, Hannon, Harris, Heringova, Hillard, Hotze, James, Jung, Komeda, Liu, Lutterman, MacDiarmid, Mackay, Mackay, McNae, Meggers, Milacic, Noor, Oleksi, Orvig, Ott, Pascu, Peacock, Peter J Sadler, Pieter CA Bruijnincx, Reed, Schatzschneider, Schlawe, Scolaro, Smalley, Sun, Thompson, Timerbaev, Urig, Urig, van Zutphen, Wang, Weidt, Yan, Yang   +56 more
core   +1 more source

Immunostaining of skeletal tissues [PDF]

, 2011
Peer ...
De Bari, Cosimo, Kurth, Tobias B
core   +1 more source