Results 71 to 80 of about 42,345 (197)
The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) [PDF]
, 2015 Thymidylate kinase (TMPK) phosphorylates thymidine 5’-monophosphate (dTMP) and has been proposed as an attractive target for Mycobacterium tuberculosis (Mt).1 By mimicking the structure of the substrate (dTMP), we have previously discovered different ...
Hulpia, Fabian +4 more
core +1 more source
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. [PDF]
, 2013 OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Aguinaga Andrés, David +19 more
core +4 more sources
Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation
Scientific Reports, 2023 SARS-CoV-2 causes the severe respiratory disease COVID-19. Remdesivir (RDV) was the first fast-tracked FDA approved treatment drug for COVID-19. RDV acts as an antiviral ribonucleoside (adenosine) analogue that becomes active once it accumulates ...
Nicole DeFoor +9 more
doaj +1 more source
Biogenesis of mitochondrial porin [PDF]
, 1990 We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann +74 more
core +1 more source
Metabolites from traditional Chinese botanical drugs with anti-hepatitis B virus activity - a review
Frontiers in PharmacologyHepatitis B virus (HBV)-related liver disease poses a major threat to human health worldwide. Although interferon and nucleoside analogues are commonly administered for treating chronic HBV infection, their use is limited by considerable side effects ...
Nannan Li +4 more
doaj +1 more source
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
core +2 more sources
Journal of Saudi Chemical Society, 2020 A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery.
Svetlana V. Vasilyeva +3 more
doaj +1 more source
N,O‐Nucleoside Analogues: Metabolic and Apoptotic Activity
ChemistryOpen, 2020 Two new families of N,O‐nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a
Dr. Andrea Marraffa +5 more
doaj +1 more source
Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals.
PLoS ONE, 2012 BackgroundInosine triphosphatase (ITPase) is encoded by the polymorphic gene ITPA and maintains low intracellular levels of the inosine nucleotides ITP and dITP. The most frequently reported polymorphisms are ITPA c.94C>A (rs 1127354) and ITPA c.
Jörgen Bierau +7 more
doaj +1 more source
Molecules, 2019 A small library of 3’-deoxy-C3’-substituted xylofuranosyl-pyrimidine nucleoside analogues were prepared by photoinduced thiol-ene addition of various thiols, including normal and branched alkyl-, 2-hydroxyethyl, benzyl-, and sugar thiols, to ...
Miklós Bege +9 more
doaj +1 more source